                                                 Toxicology Data Management System                                     Page: 1
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                    Date of
 Species: MICE                                           Vehicle: WATER                                   Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055021503  03/04/97   730       50(1)      38  (707)     53.4     ACRYLONITRILE                              |
|BATTELLE COLUMBUS  058812207  07/01/97   730       50(1)      39  (702)     52.5     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805006  10/16/95   729       49(1)      35  (704)     50.6     METHACRYLONITRILE                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055021503  03/04/97   729       50(5)      39  (709)     62.7     ACRYLONITRILE                              |
|BATTELLE COLUMBUS  058812207  07/01/97   729       50(5)      37  (692)     62.9     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805006  10/16/95   731       50(5)      35  (700)     58.1     METHACRYLONITRILE                          |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: FEED                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058813804  09/14/99   730       50(1)      44  (717)     46.0     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634804  06/19/96   727      100(1)      91  (707)     49.6     CITRAL                                     |
|BATTELLE COLUMBUS  058812004  01/04/96   733       50(1)      40  (705)     46.9     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  055611104  09/24/97   728      100(1)      91  (705)     46.5     TRANS-CINNAMALDEHYDE                       |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058813804  09/14/99   729       50(5)      40  (706)     46.2     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634804  06/19/96   733       99(5)      81  (695)     48.0     CITRAL                                     |
|BATTELLE COLUMBUS  058812004  01/04/96   734       50(5)      42  (717)     46.5     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  055611104  09/24/97   733      100(5)      84  (711)     46.0     TRANS-CINNAMALDEHYDE                       |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: WATER                                   Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058803106  03/19/97   729       50(1)      40  (703)     53.9     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058800706  08/02/95   727       50(1)      39  (708)     51.4     SODIUM NITRITE                             |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058803106  03/19/97   728       50(5)      37  (699)     61.4     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058800706  08/02/95   728       50(5)      40  (702)     58.8     SODIUM NITRITE                             |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 4
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                          Date of
 Species: MICE                                           Vehicle: ACETONE                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050510914  09/24/98   726       50(1)      37  (710)     53.4     TRIETHANOLAMINE                            |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050510914  09/24/98   729       50(1)      35  (692)     62.7     TRIETHANOLAMINE                            |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 5
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                Date of
 Species: MICE                                           Vehicle: AIR                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302606  08/28/97   733       50( )      40  (701)     54.1     DECALIN                                    |
|BATTELLE NORTHWEST 058800406  09/27/99   729       50( )      41  (702)     52.2     DIVINYLBENZENE                             |
|BATTELLE NORTHWEST 058812404  01/25/96   733       50( )      37  (711)     51.6     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 059000406  09/29/97   729       50( )      35  (703)     54.3     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600106  12/21/98   729       50( )      34  (690)     53.0     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142708  01/13/97   729       50( )      39  (710)     55.4     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302606  08/28/97   735       49( )      37  (708)     61.5     DECALIN                                    |
|BATTELLE NORTHWEST 058800406  09/27/99   731       50( )      33  (681)     63.0     DIVINYLBENZENE                             |
|BATTELLE NORTHWEST 058812404  01/25/96   735       50( )      42  (713)     54.8     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 059000406  09/29/97   731       50( )      39  (718)     59.8     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600106  12/21/98   731       50( )      36  (702)     54.6     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142708  01/13/97   731       50( )      38  (692)     58.7     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 6
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                Date of
 Species: MICE                                           Vehicle: AIR                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE TOXICOLOGY059700602T 06/05/00   729       50( )      40  (709)     53.2     METHYL ISOBUTYL KETONE                     |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE TOXICOLOGY059700602T 06/05/00   731       50( )      35  (695)     60.3     METHYL ISOBUTYL KETONE                     |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 7
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                           Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902906  10/05/94   734      100(1)      76  (711)     53.4     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902906  10/05/94   735      100(5)      70  (702)     59.7     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 8
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                    Date of
 Species: MICE                                           Vehicle: CORN OIL                                Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302307  07/25/97   729       50(1)      44  (721)     57.3     2,4-HEXADIENAL                             |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302307  07/25/97   732       50(5)      42  (717)     64.2     2,4-HEXADIENAL                             |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 9
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                    Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                        Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  050516106  03/20/96   729       50(1)      39  (696)     51.4     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  050516106  03/20/96   735       50(5)      34  (674)     59.5     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 10
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: FEED                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059201206  07/29/98   729       50(1)      43  (706)     46.8     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059201306  02/03/00   729       50(1)      45  (717)     46.1     4-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  050520309  02/20/96   729       60(1)      52  (712)     48.0     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   729       50(1)      46  (722)     47.4     P-NITROTOLUENE                             |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059201206  07/29/98   732       50(5)      46  (720)     38.8     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059201306  02/03/00   734       50(5)      42  (706)     45.6     4-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  050520309  02/20/96   731       60(5)      52  (708)     46.6     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   732       50(5)      46  (727)     41.4     P-NITROTOLUENE                             |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 11
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: WATER                                   Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059601004  09/30/98   729       50(1)      38  (694)     54.1     SODIUM DICHLORATE                          |
|SOUTHERN RESEARCH  059601804  12/15/98   9999       0(5)       0  (  0)     N/A      BROMODICHLOROMETHANE                       |
|SOUTHERN RESEARCH  059601706  02/23/00   729       49(1)      31  (685)     52.5     DIBROMOACETIC ACID                         |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059601004  09/30/98   735       50(5)      36  (691)     66.5     SODIUM DICHLORATE                          |
|SOUTHERN RESEARCH  059601804  12/15/98   729       50(5)      36  (699)     66.6     BROMODICHLOROMETHANE                       |
|SOUTHERN RESEARCH  059601706  02/23/00   734       50(5)      38  (708)     64.3     DIBROMOACETIC ACID                         |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 12
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                          Date of
 Species: MICE                                           Vehicle: ETHANOL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302008  05/08/00   729       50(1)      39  (710)     52.6     DIISOPROPYLCARBODIIMIDE                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302008  05/08/00   732       50(1)      33  (674)     65.7     DIISOPROPYLCARBODIIMIDE                    |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 13
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       34/50 (68%)   29/50 (58%)   29/49 (59%)         29/50 (58%)   17/50 (34%)   24/50 (48%)    |
| Overall Incidence               Total 92/149 (61.74%) Mean 61.73%  SD 5.46%     Total 70/150 (46.67%)  Mean 46.67%  SD 12.06%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    29/50 (58%)   24/50 (48%)   24/49 (49%)         24/50 (48%)   17/50 (34%)   20/50 (40%)    |
| Overall Incidence               Total 77/149 (51.68%) Mean 51.66%  SD 5.51%     Total 61/150 (40.67%)  Mean 40.67%  SD 7.02%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)   38/50 (76%)   40/49 (82%)         39/50 (78%)   29/50 (58%)   34/50 (68%)    |
| Overall Incidence               Total 123/149 (82.55%)Mean 82.54%  SD 7.04%     Total 102/150 (68%)    Mean 68%     SD 10%       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 2/149 (1.34%)   Mean 1.33%   SD 2.31%     Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)     6/50 (12%)    3/49 (6%)           4/50 (8%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 12/149 (8.05%)  Mean 8.04%   SD 3.43%     Total 7/150 (4.67%)    Mean 4.67%   SD 3.06%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        5/50 (10%)    6/50 (12%)    3/49 (6%)           4/50 (8%)     1/50 (2%)     4/50 (8%)     |
| Overall Incidence               Total 14/149 (9.4%)   Mean 9.37%   SD 2.99%     Total 9/150 (6%)       Mean 6%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/50 (2%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)     3/50 (6%)     2/49 (4%)           4/50 (8%)     7/50 (14%)    9/50 (18%)    |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 8/149 (5.37%)   Mean 5.36%   SD 1.11%     Total 20/150 (13.33%)  Mean 13.33%  SD 5.03%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                                                                                                                         |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/50 (6%)     2/50 (4%)     5/49 (10%)          0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 10/149 (6.71%)  Mean 6.73%   SD 3.17%     Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      2/50 (4%)     2/50 (4%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/149 (2.68%)   Mean 2.67%   SD 2.31%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/50 (0%)     0/40 (0%)     0/46 (0%)           0/50 (0%)     0/39 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/136 (0%)      Mean 0%      SD 0%        Total 0/139 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/50 (0%)     0/40 (0%)     0/46 (0%)           0/50 (0%)     0/39 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/136 (0%)      Mean 0%      SD 0%        Total 0/139 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              5/50 (10%)    6/50 (12%)    3/49 (6%)          10/50 (20%)    4/50 (8%)     2/50 (4%)     |
| Overall Incidence               Total 14/149 (9.4%)   Mean 9.37%   SD 2.99%     Total 16/150 (10.67%)  Mean 10.67%  SD 8.33%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 6/50 (12%)    6/50 (12%)    3/49 (6%)          11/50 (22%)    4/50 (8%)     4/50 (8%)     |
| Overall Incidence               Total 15/149 (10.07%) Mean 10.04%  SD 3.39%     Total 19/150 (12.67%)  Mean 12.67%  SD 8.08%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 1/50 (2%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/148 (0.68%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/149 (1.34%)   Mean 1.36%   SD 2.36%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            2/50 (4%)     4/50 (8%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 7/149 (4.7%)    Mean 4.68%   SD 3.04%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/149 (1.34%)   Mean 1.36%   SD 2.36%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            2/50 (4%)     4/50 (8%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 7/149 (4.7%)    Mean 4.68%   SD 3.04%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 2/50 (4%)     4/50 (8%)     3/49 (6%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 9/149 (6.04%)   Mean 6.04%   SD 2%        Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/50 (4%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/149 (2.68%)   Mean 2.69%   SD 2.33%     Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/149 (2.68%)   Mean 2.69%   SD 2.33%     Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/148 (0.68%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/50 (4%)     2/50 (4%)     1/49 (2%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 5/149 (3.36%)   Mean 3.35%   SD 1.13%     Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/149 (1.34%)   Mean 1.35%   SD 1.17%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              23/50 (46%)   19/50 (38%)   17/49 (35%)         14/50 (28%)    7/50 (14%)    9/50 (18%)    |
| Overall Incidence               Total 59/149 (39.6%)  Mean 39.56%  SD 5.81%     Total 30/150 (20%)     Mean 20%     SD 7.21%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            14/50 (28%)   11/50 (22%)   13/49 (27%)          7/50 (14%)    3/50 (6%)     2/50 (4%)     |
| Overall Incidence               Total 38/149 (25.5%)  Mean 25.51%  SD 3.13%     Total 12/150 (8%)      Mean 8%      SD 5.29%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         14/50 (28%)   12/50 (24%)   14/49 (29%)          7/50 (14%)    3/50 (6%)     2/50 (4%)     |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 40/149 (26.85%) Mean 26.86%  SD 2.49%     Total 12/150 (8%)      Mean 8%      SD 5.29%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         32/50 (64%)   23/50 (46%)   24/49 (49%)         20/50 (40%)   10/50 (20%)   10/50 (20%)    |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 79/149 (53.02%) Mean 52.99%  SD 9.65%     Total 40/150 (26.67%)  Mean 26.67%  SD 11.55%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           32/50 (64%)   24/50 (48%)   24/49 (49%)         20/50 (40%)   10/50 (20%)   10/50 (20%)    |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 80/149 (53.69%) Mean 53.66%  SD 8.97%     Total 40/150 (26.67%)  Mean 26.67%  SD 11.55%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.68%   SD 1.18%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        10/50 (20%)   10/50 (20%)    2/49 (4%)           4/50 (8%)     2/50 (4%)     6/50 (12%)    |
| Overall Incidence               Total 22/149 (14.77%) Mean 14.69%  SD 9.19%     Total 12/150 (8%)      Mean 8%      SD 4%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       4/50 (8%)     5/50 (10%)    4/49 (8%)           2/50 (4%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 13/149 (8.72%)  Mean 8.72%   SD 1.11%     Total 4/150 (2.67%)    Mean 2.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)   14/50 (28%)    6/49 (12%)          6/50 (12%)    3/50 (6%)     6/50 (12%)    |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 34/149 (22.82%) Mean 22.75%  SD 9.1%      Total 15/150 (10%)     Mean 10%     SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/149 (1.34%)   Mean 1.33%   SD 2.31%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          8/50 (16%)    1/47 (2%)     2/50 (4%)     |
| Overall Incidence                                                               Total 11/147 (7.48%)   Mean 7.38%   SD 7.53%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/47 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)     0/47 (0%)     2/50 (4%)     |
| Overall Incidence                                                               Total 2/147 (1.36%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/47 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/47 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     0/47 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/147 (0.68%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)     0/47 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/47 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/146 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/47 (0%)     0/48 (0%)           2/48 (4%)     2/48 (4%)     2/49 (4%)     |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/144 (0%)      Mean 0%      SD 0%        Total 6/145 (4.14%)    Mean 4.14%   SD 0.05%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/47 (0%)     0/48 (0%)           0/48 (0%)     0/48 (0%)     0/49 (0%)     |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/144 (0%)      Mean 0%      SD 0%        Total 0/145 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/47 (0%)     0/48 (0%)           2/48 (4%)     2/48 (4%)     2/49 (4%)     |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/144 (0%)      Mean 0%      SD 0%        Total 6/145 (4.14%)    Mean 4.14%   SD 0.05%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/49 (2%)     0/47 (0%)     0/48 (0%)           0/48 (0%)     0/48 (0%)     2/49 (4%)     |
| Overall Incidence               Total 1/144 (0.69%)   Mean 0.68%   SD 1.18%     Total 2/145 (1.38%)    Mean 1.36%   SD 2.36%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/49 (2%)     0/47 (0%)     0/48 (0%)           0/48 (0%)     0/48 (0%)     2/49 (4%)     |
| Overall Incidence               Total 1/144 (0.69%)   Mean 0.68%   SD 1.18%     Total 2/145 (1.38%)    Mean 1.36%   SD 2.36%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/49 (2%)                                                     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.68%   SD 1.18%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%                                                      |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.68%   SD 1.18%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 26
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.68%   SD 1.18%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.68%   SD 1.18%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 27
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.68%   SD 1.18%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.68%   SD 1.18%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     0/49 (0%)           3/50 (6%)     3/50 (6%)     2/50 (4%)     |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 8/150 (5.33%)    Mean 5.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 4/150 (2.67%)    Mean 2.67%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     0/49 (0%)           3/50 (6%)     3/50 (6%)     2/50 (4%)     |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 8/150 (5.33%)    Mean 5.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     3/50 (6%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 4/150 (2.67%)    Mean 2.67%   SD 3.06%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)     0/49 (0%)     1/49 (2%)           0/50 (0%)     0/47 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/148 (1.35%)   Mean 1.35%   SD 1.17%     Total 1/147 (0.68%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/147 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           3/50 (6%)     0/50 (0%)     1/49 (2%)           3/50 (6%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 4/149 (2.68%)   Mean 2.68%   SD 3.05%     Total 3/150 (2%)       Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              3/50 (6%)     0/50 (0%)     1/49 (2%)           3/50 (6%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/149 (2.68%)   Mean 2.68%   SD 3.05%     Total 3/150 (2%)       Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/49 (0%)                                                     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|      Malignant, NOS                                                                                                              |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/47 (0%)     0/40 (0%)     0/40 (0%)           0/50 (0%)     0/43 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/127 (0%)      Mean 0%      SD 0%        Total 0/140 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/47 (0%)     0/40 (0%)     0/40 (0%)           0/50 (0%)     0/43 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/127 (0%)      Mean 0%      SD 0%        Total 0/140 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/47 (0%)     0/40 (0%)     0/40 (0%)           0/50 (0%)     0/43 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/127 (0%)      Mean 0%      SD 0%        Total 0/140 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/47 (0%)     0/40 (0%)     0/40 (0%)           0/50 (0%)     0/43 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/127 (0%)      Mean 0%      SD 0%        Total 0/140 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/147 (0%)      Mean 0%      SD 0%        Total 0/145 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     1/49 (2%)           0/50 (0%)     0/46 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/147 (0.68%)   Mean 0.68%   SD 1.18%     Total 0/145 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/48 (0%)     1/49 (2%)           0/50 (0%)     0/46 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/147 (0.68%)   Mean 0.68%   SD 1.18%     Total 0/145 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     0/48 (0%)     0/49 (0%)           2/50 (4%)     0/46 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/147 (0%)      Mean 0%      SD 0%        Total 2/145 (1.38%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     1/49 (2%)           0/50 (0%)     0/46 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/147 (0.68%)   Mean 0.68%   SD 1.18%     Total 0/145 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/48 (0%)     1/49 (2%)           2/50 (4%)     0/46 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/147 (0.68%)   Mean 0.68%   SD 1.18%     Total 2/145 (1.38%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.68%   SD 1.18%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/143 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/143 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/143 (0.7%)     Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/143 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/143 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     3/50 (6%)     0/50 (0%)     |
| Overall Incidence                                                               Total 3/150 (2%)       Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     3/50 (6%)     0/50 (0%)     |
| Overall Incidence                                                               Total 3/150 (2%)       Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       27/50 (54%)   40/100(40%)   16/50 (32%)         15/50 (30%)   28/99 (28%)   15/50 (30%)    |
|                                       37/100(37%)                                     32/100(32%)                                |
| Overall Incidence               Total 120/300 (40%)   Mean 40.75%  SD 9.43%     Total 90/299 (30.1%)   Mean 30.07%  SD 1.52%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    17/50 (34%)   32/100(32%)   21/50 (42%)         16/50 (32%)   24/99 (24%)   12/50 (24%)    |
|                                       28/100(28%)                                     46/100(46%)                                |
| Overall Incidence               Total 98/300 (32.67%) Mean 34%     SD 5.89%     Total 98/299 (32.78%)  Mean 31.56%  SD 10.32%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         38/50 (76%)   55/100(55%)   32/50 (64%)         25/50 (50%)   45/99 (45%)   23/50 (46%)    |
|                                       57/100(57%)                                     62/100(62%)                                |
| Overall Incidence               Total 182/300 (60.67%)Mean 63%     SD 9.49%     Total 155/299 (51.84%) Mean 50.86%  SD 7.7%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     2/100(2%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        3/100(3%)                                       4/100(4%)                                 |
| Overall Incidence               Total 5/300 (1.67%)   Mean 1.25%   SD 1.5%      Total 5/299 (1.67%)    Mean 1.25%   SD 1.89%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)     3/100(3%)     3/50 (6%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        2/100(2%)                                       1/100(1%)                                 |
| Overall Incidence               Total 11/300 (3.67%)  Mean 4.25%   SD 2.06%     Total 2/299 (0.67%)    Mean 0.75%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        3/50 (6%)     5/100(5%)     3/50 (6%)           1/50 (2%)     1/99 (1%)     0/50 (0%)     |
|                                        5/100(5%)                                       5/100(5%)                                 |
| Overall Incidence               Total 16/300 (5.33%)  Mean 5.5%    SD 0.58%     Total 7/299 (2.34%)    Mean 2%      SD 2.16%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.5%    SD 1%        Total 2/299 (0.67%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)     4/100(4%)     3/50 (6%)           8/50 (16%)    7/99 (7%)     6/50 (12%)    |
|      Lymphocytic, Mixed, NOS, or       8/100(8%)                                      23/100(23%)                                |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 17/300 (5.67%)  Mean 5.5%    SD 1.91%     Total 44/299 (14.72%)  Mean 14.52%  SD 6.73%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      NOS                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 34
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     1/50 (2%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 3/299 (1%)       Mean 1.25%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     1/50 (2%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 3/299 (1%)       Mean 1.25%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     2/100(2%)     0/49 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        2/99 (2%)                                       0/100(0%)                                 |
| Overall Incidence               Total 4/298 (1.34%)   Mean 1.01%   SD 1.16%     Total 1/299 (0.33%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/49 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/49 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/99 (0%)     0/49 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 1/298 (0.34%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/99 (0%)     0/49 (0%)           0/50 (0%)     1/99 (1%)     1/50 (2%)     |
|                                        0/99 (0%)                                       1/99 (1%)                                 |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 3/298 (1.01%)    Mean 1.01%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/99 (0%)     0/49 (0%)           1/50 (2%)     1/99 (1%)     1/50 (2%)     |
|      Complex, Malignant, NOS           0/99 (0%)                                       1/99 (1%)                                 |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 4/298 (1.34%)    Mean 1.51%   SD 0.57%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/49 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 35
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/49 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)     1/100(1%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.75%   SD 0.96%     Total 1/299 (0.33%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.25%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.75%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.75%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.5%    SD 0.58%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.5%    SD 0.58%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        1/100(1%)                                                                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%                                                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/100(0%)                                                                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/45 (0%)     0/100(0%)     0/49 (0%)           0/49 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/294 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/45 (0%)     0/100(0%)     0/49 (0%)           0/49 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/294 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              6/50 (12%)    4/100(4%)     5/50 (10%)          1/50 (2%)     3/99 (3%)     3/50 (6%)     |
|                                        8/100(8%)                                       2/100(2%)                                 |
| Overall Incidence               Total 23/300 (7.67%)  Mean 8.5%    SD 3.42%     Total 9/299 (3.01%)    Mean 3.26%   SD 1.89%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.5%    SD 1%        Total 2/299 (0.67%)    Mean 0.5%    SD 0.58%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 7/50 (14%)    4/100(4%)     5/50 (10%)          1/50 (2%)     4/99 (4%)     3/50 (6%)     |
|                                        8/100(8%)                                       3/100(3%)                                 |
| Overall Incidence               Total 24/300 (8%)     Mean 9%      SD 4.16%     Total 11/299 (3.68%)   Mean 3.76%   SD 1.71%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.5%    SD 1%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 38
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 39
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     2/100(2%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 3/300 (1%)      Mean 0.75%   SD 0.96%     Total 1/299 (0.33%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     3/100(3%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       1/100(1%)                                 |
| Overall Incidence               Total 4/300 (1.33%)   Mean 1%      SD 1.41%     Total 1/299 (0.33%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     3/100(3%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       1/100(1%)                                 |
| Overall Incidence               Total 4/300 (1.33%)   Mean 1%      SD 1.41%     Total 1/299 (0.33%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     3/100(3%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       1/100(1%)                                 |
| Overall Incidence               Total 4/300 (1.33%)   Mean 1%      SD 1.41%     Total 1/299 (0.33%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     2/100(2%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 3/300 (1%)      Mean 0.75%   SD 0.96%     Total 1/299 (0.33%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 1/299 (0.33%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     2/100(2%)     2/50 (4%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 4/300 (1.33%)   Mean 1.5%    SD 1.91%     Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              11/50 (22%)   20/100(20%)    6/50 (12%)          5/50 (10%)    8/99 (8%)     4/50 (8%)     |
|                                       14/100(14%)                                      7/99 (7%)                                 |
| Overall Incidence               Total 51/300 (17%)    Mean 17%     SD 4.76%     Total 24/298 (8.05%)   Mean 8.29%   SD 1.23%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             8/50 (16%)   13/100(13%)    9/50 (18%)          0/50 (0%)     4/99 (4%)     3/50 (6%)     |
|                                       13/100(13%)                                      3/99 (3%)                                 |
| Overall Incidence               Total 43/300 (14.33%) Mean 15%     SD 2.45%     Total 10/298 (3.36%)   Mean 3.27%   SD 2.5%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          8/50 (16%)   13/100(13%)    9/50 (18%)          0/50 (0%)     4/99 (4%)     3/50 (6%)     |
|      Hepatoblastoma                   13/100(13%)                                      3/99 (3%)                                 |
| Overall Incidence               Total 43/300 (14.33%) Mean 15%     SD 2.45%     Total 10/298 (3.36%)   Mean 3.27%   SD 2.5%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         18/50 (36%)   28/100(28%)   15/50 (30%)          5/50 (10%)   12/99 (12%)    6/50 (12%)    |
|      Hepatocellular Adenoma           26/100(26%)                                      9/99 (9%)                                 |
| Overall Incidence               Total 87/300 (29%)    Mean 30%     SD 4.32%     Total 32/298 (10.74%)  Mean 10.8%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           18/50 (36%)   28/100(28%)   15/50 (30%)          5/50 (10%)   12/99 (12%)    6/50 (12%)    |
|      Hepatocellular Adenoma, or       26/100(26%)                                      9/99 (9%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 87/300 (29%)    Mean 30%     SD 4.32%     Total 32/298 (10.74%)  Mean 10.8%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 42
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        14/50 (28%)   12/100(12%)    6/50 (12%)          0/50 (0%)     5/99 (5%)     0/50 (0%)     |
|                                        9/100(9%)                                       3/100(3%)                                 |
| Overall Incidence               Total 41/300 (13.67%) Mean 15.25%  SD 8.62%     Total 8/299 (2.68%)    Mean 2.01%   SD 2.47%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       2/50 (4%)     9/100(9%)     7/50 (14%)          1/50 (2%)     6/99 (6%)     0/50 (0%)     |
|                                        7/100(7%)                                       2/100(2%)                                 |
| Overall Incidence               Total 25/300 (8.33%)  Mean 8.5%    SD 4.2%      Total 9/299 (3.01%)    Mean 2.52%   SD 2.54%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   16/50 (32%)   20/100(20%)   13/50 (26%)          1/50 (2%)    11/99 (11%)    0/50 (0%)     |
|      Alveolar/Bronchiolar Adenoma     14/100(14%)                                      5/100(5%)                                 |
| Overall Incidence               Total 63/300 (21%)    Mean 23%     SD 7.75%     Total 17/299 (5.69%)   Mean 4.53%   SD 4.85%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 43
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 44
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|      or Adenoma                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/96 (0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/296 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/96 (0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/296 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/96 (0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/296 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 45
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.25%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 1/299 (0.33%)    Mean 0.25%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/49 (2%)     3/99 (3%)     2/50 (4%)     |
|                                                                                        2/100(2%)                                 |
| Overall Incidence                                                               Total 8/298 (2.68%)    Mean 2.77%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/49 (0%)     1/99 (1%)     1/50 (2%)     |
|                                                                                        1/100(1%)                                 |
| Overall Incidence                                                               Total 3/298 (1.01%)    Mean 1%      SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/49 (0%)     1/99 (1%)     1/50 (2%)     |
|      Malignant, NOS                                                                    1/100(1%)                                 |
| Overall Incidence                                                               Total 3/298 (1.01%)    Mean 1%      SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        1/100(1%)                                 |
| Overall Incidence                                                               Total 1/298 (0.34%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        1/100(1%)                                 |
| Overall Incidence                                                               Total 1/298 (0.34%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 46
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/49 (0%)     1/99 (1%)     0/50 (0%)     |
|                                                                                        2/100(2%)                                 |
| Overall Incidence                                                               Total 3/298 (1.01%)    Mean 0.75%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        1/100(1%)                                 |
| Overall Incidence                                                               Total 1/298 (0.34%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                1/49 (2%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 1/298 (0.34%)    Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/98 (0%)     0/49 (0%)           2/50 (4%)     8/97 (8%)     3/48 (6%)     |
|   Adenoma                              0/98 (0%)                                      11/97 (11%)                                |
| Overall Incidence               Total 0/293 (0%)      Mean 0%      SD 0%        Total 24/292 (8.22%)   Mean 7.46%   SD 3.12%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/98 (0%)     0/49 (0%)           0/50 (0%)     0/97 (0%)     0/48 (0%)     |
|   Carcinoma                            0/98 (0%)                                       0/97 (0%)                                 |
| Overall Incidence               Total 0/293 (0%)      Mean 0%      SD 0%        Total 0/292 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/98 (0%)     0/49 (0%)           2/50 (4%)     8/97 (8%)     3/48 (6%)     |
|   Carcinoma or Adenoma                 0/98 (0%)                                      11/97 (11%)                                |
| Overall Incidence               Total 0/293 (0%)      Mean 0%      SD 0%        Total 24/292 (8.22%)   Mean 7.46%   SD 3.12%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/98 (0%)     0/49 (0%)           0/50 (0%)     2/97 (2%)     1/48 (2%)     |
|                                        1/98 (1%)                                       0/97 (0%)                                 |
| Overall Incidence               Total 1/293 (0.34%)   Mean 0.26%   SD 0.51%     Total 3/292 (1.03%)    Mean 1.04%   SD 1.2%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 47
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     0/98 (0%)     0/49 (0%)           0/50 (0%)     2/97 (2%)     1/48 (2%)     |
|                                        1/98 (1%)                                       0/97 (0%)                                 |
| Overall Incidence               Total 1/293 (0.34%)   Mean 0.26%   SD 0.51%     Total 3/292 (1.03%)    Mean 1.04%   SD 1.2%      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/100(0%)                                                                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/100(0%)                                                                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/100(0%)                                                                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/49 (0%)     |
|                                        0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/49 (0%)     |
|                                        0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/100(0%)                                                                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/100(0%)                                                                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.5%    SD 1%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 48
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.25%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/100(0%)                                       0/100(0%)                                 |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/100(0%)                                       0/100(0%)                                 |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 49
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/100(0%)                                       0/100(0%)                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    1/100(1%)                                       1/100(1%)                                 |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 1/299 (0.33%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        2/100(2%)                                       1/100(1%)                                 |
| Overall Incidence               Total 3/300 (1%)      Mean 0.75%   SD 0.96%     Total 2/299 (0.67%)    Mean 0.5%    SD 0.58%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.5%    SD 1%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 50
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/100(0%)                                       1/100(1%)                                 |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Papilloma                         1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          1/100(1%)                                       1/100(1%)                                 |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 1/299 (0.33%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     1/100(1%)     0/50 (0%)           1/50 (2%)     2/99 (2%)     1/50 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/100(0%)                                       4/100(4%)                                 |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 8/299 (2.68%)    Mean 2.51%   SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 51
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     1/100(1%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       4/100(4%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 5/299 (1.67%)    Mean 1.5%    SD 1.91%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     1/100(1%)     0/50 (0%)           1/50 (2%)     2/99 (2%)     1/50 (2%)     |
|      Myxosarcoma, or Fibrous           0/100(0%)                                       4/100(4%)                                 |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 8/299 (2.68%)    Mean 2.51%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      1/50 (2%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.5%    SD 1%        Total 3/299 (1%)       Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     1/50 (2%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/100(0%)                                       2/100(2%)                                 |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.5%    SD 1%        Total 3/299 (1%)       Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     2/99 (2%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.51%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 1/50 (2%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.5%    SD 1%        Total 3/299 (1%)       Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        0/100(0%)                                       0/97 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        1/100(1%)                                       0/97 (0%)                                 |
| Overall Incidence               Total 3/300 (1%)      Mean 1.25%   SD 0.96%     Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 52
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        0/100(0%)                                       0/97 (0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%      Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        0/100(0%)                                       0/97 (0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)     0/100(0%)     0/50 (0%)           2/50 (4%)     1/99 (1%)     0/50 (0%)     |
|      Papilloma Squamous                0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.5%    SD 1%        Total 4/299 (1.34%)    Mean 1.5%    SD 1.73%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/100(0%)     0/50 (0%)           1/50 (2%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.5%    SD 1%        Total 3/299 (1%)       Mean 1%      SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     1/100(1%)     1/50 (2%)                                                     |
|                                        1/100(1%)                                                                                 |
| Overall Incidence               Total 3/300 (1%)      Mean 1%      SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 53
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     1/100(1%)     0/50 (0%)                                                     |
|                                        0/100(0%)                                                                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%                                                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        1/100(1%)                                                                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.25%   SD 0.5%                                                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|      Malignant, NOS                    0/100(0%)                                                                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/100(0%)                                                                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/46 (0%)     0/99 (0%)     0/45 (0%)           0/46 (0%)     0/95 (0%)     0/49 (0%)     |
|                                        0/87 (0%)                                       0/93 (0%)                                 |
| Overall Incidence               Total 0/277 (0%)      Mean 0%      SD 0%        Total 0/283 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/46 (0%)     0/99 (0%)     0/45 (0%)           0/46 (0%)     0/95 (0%)     0/49 (0%)     |
|                                        0/87 (0%)                                       0/93 (0%)                                 |
| Overall Incidence               Total 0/277 (0%)      Mean 0%      SD 0%        Total 0/283 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/46 (0%)     0/99 (0%)     0/45 (0%)           0/46 (0%)     0/95 (0%)     0/49 (0%)     |
|                                        0/87 (0%)                                       0/93 (0%)                                 |
| Overall Incidence               Total 0/277 (0%)      Mean 0%      SD 0%        Total 0/283 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/46 (0%)     0/99 (0%)     0/45 (0%)           0/46 (0%)     0/95 (0%)     0/49 (0%)     |
|                                        0/87 (0%)                                       0/93 (0%)                                 |
| Overall Incidence               Total 0/277 (0%)      Mean 0%      SD 0%        Total 0/283 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/50 (0%)     |
|                                        0/99 (0%)                                       0/98 (0%)                                 |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/50 (0%)     |
|                                        0/99 (0%)                                       0/98 (0%)                                 |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 54
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/50 (0%)     |
|                                        0/99 (0%)                                       0/98 (0%)                                 |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)     1/100(1%)     1/50 (2%)           0/50 (0%)     0/97 (0%)     2/50 (4%)     |
|                                        1/99 (1%)                                       1/98 (1%)                                 |
| Overall Incidence               Total 4/299 (1.34%)   Mean 1.5%    SD 0.57%     Total 3/295 (1.02%)    Mean 1.26%   SD 1.89%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/50 (0%)     |
|                                        0/99 (0%)                                       0/98 (0%)                                 |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     1/100(1%)     1/50 (2%)           0/50 (0%)     0/97 (0%)     2/50 (4%)     |
|                                        1/99 (1%)                                       1/98 (1%)                                 |
| Overall Incidence               Total 4/299 (1.34%)   Mean 1.5%    SD 0.57%     Total 3/295 (1.02%)    Mean 1.26%   SD 1.89%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.25%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|      Papilloma Squamous                0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.25%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 55
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.5%    SD 1%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 56
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        1/100(1%)                                 |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        1/100(1%)                                 |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.25%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        4/50 (8%)     2/99 (2%)     1/50 (2%)     |
|                                                                                        1/100(1%)                                 |
| Overall Incidence                                                               Total 8/299 (2.68%)    Mean 3.26%   SD 3.2%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     5/50 (10%)    2/99 (2%)     1/50 (2%)     |
|                                                                                        1/100(1%)                                 |
| Overall Incidence                                                               Total 9/299 (3.01%)    Mean 3.76%   SD 4.19%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 57
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

                                                This page intentionally left blank
                                                 Toxicology Data Management System                                     Page: 59
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       27/50 (54%)   28/50 (56%)                       22/50 (44%)   13/50 (26%)                  |
| Overall Incidence               Total 55/100 (55%)    Mean 55%     SD 1.41%     Total 35/100 (35%)     Mean 35%     SD 12.73%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    19/50 (38%)   27/50 (54%)                       18/50 (36%)   12/50 (24%)                  |
| Overall Incidence               Total 46/100 (46%)    Mean 46%     SD 11.31%    Total 30/100 (30%)     Mean 30%     SD 8.49%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         39/50 (78%)   40/50 (80%)                       32/50 (64%)   21/50 (42%)                  |
| Overall Incidence               Total 79/100 (79%)    Mean 79%     SD 1.41%     Total 53/100 (53%)     Mean 53%     SD 15.56%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)     0/50 (0%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     7/50 (14%)                        3/50 (6%)     1/50 (2%)                   |
| Overall Incidence               Total 7/100 (7%)      Mean 7%      SD 9.9%      Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        2/50 (4%)     7/50 (14%)                        5/50 (10%)    1/50 (2%)                   |
| Overall Incidence               Total 9/100 (9%)      Mean 9%      SD 7.07%     Total 6/100 (6%)       Mean 6%      SD 5.66%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     1/50 (2%)     1/50 (2%)                         5/50 (10%)    7/50 (14%)                  |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 12/100 (12%)     Mean 12%     SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      NOS                                                                                                                         |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 60
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 61
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 62
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/48 (0%)     0/50 (0%)                         0/50 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/48 (0%)     0/50 (0%)                         0/50 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              2/50 (4%)     4/50 (8%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 2.83%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)     4/50 (8%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 7/100 (7%)      Mean 7%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 63
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    1/50 (2%)     2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 64
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/50 (2%)     5/50 (10%)                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 5.66%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/50 (2%)     5/50 (10%)                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 5.66%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)     5/50 (10%)                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 5.66%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    2/50 (4%)     2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)     3/50 (6%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 4.24%     Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     3/50 (6%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 4.24%     Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 65
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           1/50 (2%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     2/50 (4%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     5/50 (10%)                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 5/100 (5%)      Mean 5%      SD 7.07%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              17/50 (34%)   19/50 (38%)                       11/50 (22%)    9/50 (18%)                  |
| Overall Incidence               Total 36/100 (36%)    Mean 36%     SD 2.83%     Total 20/100 (20%)     Mean 20%     SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            14/50 (28%)    9/50 (18%)                        7/50 (14%)    2/50 (4%)                   |
| Overall Incidence               Total 23/100 (23%)    Mean 23%     SD 7.07%     Total 9/100 (9%)       Mean 9%      SD 7.07%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         14/50 (28%)   12/50 (24%)                        7/50 (14%)    2/50 (4%)                   |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 26/100 (26%)    Mean 26%     SD 2.83%     Total 9/100 (9%)       Mean 9%      SD 7.07%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         29/50 (58%)   24/50 (48%)                       17/50 (34%)   10/50 (20%)                  |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 53/100 (53%)    Mean 53%     SD 7.07%     Total 27/100 (27%)     Mean 27%     SD 9.9%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           29/50 (58%)   26/50 (52%)                       17/50 (34%)   10/50 (20%)                  |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 55/100 (55%)    Mean 55%     SD 4.24%     Total 27/100 (27%)     Mean 27%     SD 9.9%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 66
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         3/50 (6%)    10/50 (20%)                        2/50 (4%)     1/50 (2%)                   |
| Overall Incidence               Total 13/100 (13%)    Mean 13%     SD 9.9%      Total 3/100 (3%)       Mean 3%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       3/50 (6%)     4/50 (8%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 7/100 (7%)      Mean 7%      SD 1.41%     Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    6/50 (12%)   13/50 (26%)                        3/50 (6%)     1/50 (2%)                   |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 19/100 (19%)    Mean 19%     SD 9.9%      Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 67
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)                         2/50 (4%)     0/50 (0%)                   |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 68
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/50 (2%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 1/97 (1.03%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 69
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/50 (2%)     0/47 (0%)                   |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 1/97 (1.03%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/47 (0%)                   |
| Overall Incidence                                                               Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/49 (0%)                         1/49 (2%)     1/48 (2%)                   |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 2/97 (2.06%)     Mean 2.06%   SD 0.03%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/49 (0%)                         0/49 (0%)     0/48 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/49 (0%)                         1/49 (2%)     1/48 (2%)                   |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 2/97 (2.06%)     Mean 2.06%   SD 0.03%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 70
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/49 (2%)     0/49 (0%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 1/98 (1.02%)    Mean 1.02%   SD 1.44%     Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/49 (2%)     0/49 (0%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 1/98 (1.02%)    Mean 1.02%   SD 1.44%     Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 71
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 72
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 73
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)                         3/50 (6%)     1/50 (2%)                   |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)                         3/50 (6%)     1/50 (2%)                   |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 74
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         3/50 (6%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     3/50 (6%)                         1/50 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 4.24%     Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)     1/50 (2%)                         2/50 (4%)     1/50 (2%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 3/100 (3%)       Mean 3%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     1/50 (2%)                         2/50 (4%)     1/50 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 3/100 (3%)       Mean 3%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 75
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              3/50 (6%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 4.24%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)     0/50 (0%)                                                                   |
|      Malignant, NOS                                                                                                              |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/46 (0%)     0/37 (0%)                         1/49 (2%)     0/46 (0%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 1/95 (1.05%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/46 (0%)     0/37 (0%)                         0/49 (0%)     1/46 (2%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 1/95 (1.05%)     Mean 1.09%   SD 1.54%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/46 (0%)     0/37 (0%)                         0/49 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 0/95 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/46 (0%)     0/37 (0%)                         0/49 (0%)     1/46 (2%)                   |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 1/95 (1.05%)     Mean 1.09%   SD 1.54%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 76
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 77
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 78
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 79
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       30/50 (60%)                                     24/50 (48%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    28/50 (56%)                                     27/50 (54%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)                                     38/50 (76%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        4/50 (8%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)                                       8/50 (16%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)                                       0/50 (0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 80
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/50 (2%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/50 (2%)                                       1/49 (2%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 81
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 82
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              7/50 (14%)                                      5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 7/50 (14%)                                      7/50 (14%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 83
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 84
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 85
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              19/50 (38%)                                      9/50 (18%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            17/50 (34%)                                      6/50 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         18/50 (36%)                                      6/50 (12%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         33/50 (66%)                                     12/50 (24%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           33/50 (66%)                                     12/50 (24%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 86
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         6/50 (12%)                                      3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       7/50 (14%)                                      2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   12/50 (24%)                                      5/50 (10%)                                |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 87
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       0/50 (0%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 88
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 89
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)                                       8/50 (16%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)                                       8/50 (16%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 90
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 91
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)                                       0/50 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 92
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 93
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)                                       1/50 (2%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)                                       1/50 (2%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 94
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      2/49 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)                                       2/50 (4%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 95
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)                                                                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 96
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 97
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 98
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 99
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       32/50 (64%)   35/50 (70%)   29/50 (58%)         28/49 (57%)   28/50 (56%)   25/50 (50%)    |
|                                       30/50 (60%)   32/50 (64%)   31/50 (62%)         25/50 (50%)   27/50 (54%)   19/50 (38%)    |
| Overall Incidence               Total 189/300 (63%)   Mean 63%     SD 4.15%     Total 152/299 (50.84%) Mean 50.86%  SD 6.97%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    23/50 (46%)   26/50 (52%)   21/50 (42%)         22/49 (45%)   22/50 (44%)   20/50 (40%)    |
|                                       22/50 (44%)   23/50 (46%)   27/50 (54%)         23/50 (46%)   19/50 (38%)   17/50 (34%)    |
| Overall Incidence               Total 142/300 (47.33%)Mean 47.33%  SD 4.68%     Total 123/299 (41.14%) Mean 41.15%  SD 4.65%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         43/50 (86%)   43/50 (86%)   41/50 (82%)         39/49 (80%)   40/50 (80%)   35/50 (70%)    |
|                                       41/50 (82%)   42/50 (84%)   42/50 (84%)         37/50 (74%)   39/50 (78%)   32/50 (64%)    |
| Overall Incidence               Total 252/300 (84%)   Mean 84%     SD 1.79%     Total 222/299 (74.25%) Mean 74.27%  SD 6.31%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/300 (0.67%)   Mean 0.67%   SD 1.03%     Total 4/299 (1.34%)    Mean 1.34%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)     6/50 (12%)    3/50 (6%)           1/49 (2%)     1/50 (2%)     3/50 (6%)     |
|                                        3/50 (6%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 15/300 (5%)     Mean 5%      SD 3.95%     Total 9/299 (3.01%)    Mean 3.01%   SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/50 (2%)     6/50 (12%)    3/50 (6%)           2/49 (4%)     2/50 (4%)     4/50 (8%)     |
|                                        4/50 (8%)     2/50 (4%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence               Total 17/300 (5.67%)  Mean 5.67%   SD 3.88%     Total 13/299 (4.35%)   Mean 4.35%   SD 1.96%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     3/50 (6%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 8/299 (2.68%)    Mean 2.67%   SD 2.07%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)     1/50 (2%)     1/50 (2%)          11/49 (22%)   11/50 (22%)    8/50 (16%)    |
|      Lymphocytic, Mixed, NOS, or       3/50 (6%)     3/50 (6%)     2/50 (4%)          13/50 (26%)    5/50 (10%)    7/50 (14%)    |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 13/300 (4.33%)  Mean 4.33%   SD 1.97%     Total 55/299 (18.39%)  Mean 18.41%  SD 6.05%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 100
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              2/49 (4%)     3/49 (6%)     2/50 (4%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/48 (2%)     4/49 (8%)     1/50 (2%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 13/295 (4.41%)  Mean 4.41%   SD 2.39%     Total 2/298 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 1/298 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)     2/49 (4%)     0/50 (0%)           2/48 (4%)     0/49 (0%)     2/49 (4%)     |
|                                        0/47 (0%)     0/48 (0%)     0/50 (0%)           0/47 (0%)     1/49 (2%)     2/49 (4%)     |
| Overall Incidence               Total 2/293 (0.68%)   Mean 0.68%   SD 1.67%     Total 7/291 (2.41%)    Mean 2.4%    SD 2.02%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/50 (0%)           0/47 (0%)     1/49 (2%)     0/49 (0%)     |
| Overall Incidence               Total 0/293 (0%)      Mean 0%      SD 0%        Total 1/291 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)     2/49 (4%)     0/50 (0%)           2/48 (4%)     0/49 (0%)     2/49 (4%)     |
|      Complex, Malignant, NOS           0/47 (0%)     0/48 (0%)     0/50 (0%)           0/47 (0%)     2/49 (4%)     2/49 (4%)     |
| Overall Incidence               Total 2/293 (0.68%)   Mean 0.68%   SD 1.67%     Total 8/291 (2.75%)    Mean 2.74%   SD 2.12%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      1/49 (2%)     2/50 (4%)     1/49 (2%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 4/296 (1.35%)   Mean 1.35%   SD 1.64%     Total 2/296 (0.68%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 101
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/49 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/296 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)     1/50 (2%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/296 (0.34%)   Mean 0.33%   SD 0.82%     Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 102
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 103
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/42 (0%)     1/42 (2%)     0/43 (0%)           0/41 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/42 (0%)           0/40 (0%)     0/40 (0%)     0/46 (0%)     |
| Overall Incidence               Total 1/246 (0.41%)   Mean 0.4%    SD 0.97%     Total 0/258 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/42 (0%)     0/42 (0%)     0/43 (0%)           0/41 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/42 (0%)           0/40 (0%)     0/40 (0%)     0/46 (0%)     |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/258 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              6/50 (12%)    5/50 (10%)    1/50 (2%)           3/49 (6%)     4/50 (8%)     3/50 (6%)     |
|                                        6/50 (12%)    7/50 (14%)    8/50 (16%)          3/50 (6%)     4/50 (8%)     2/50 (4%)     |
| Overall Incidence               Total 33/300 (11%)    Mean 11%     SD 4.86%     Total 19/299 (6.35%)   Mean 6.35%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            3/50 (6%)     1/50 (2%)     0/50 (0%)           1/49 (2%)     2/50 (4%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 5/300 (1.67%)   Mean 1.67%   SD 2.34%     Total 4/299 (1.34%)    Mean 1.34%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 9/50 (18%)    6/50 (12%)    1/50 (2%)           4/49 (8%)     6/50 (12%)    3/50 (6%)     |
|                                        7/50 (14%)    7/50 (14%)    8/50 (16%)          3/50 (6%)     5/50 (10%)    2/50 (4%)     |
| Overall Incidence               Total 38/300 (12.67%) Mean 12.67%  SD 5.61%     Total 23/299 (7.69%)   Mean 7.69%   SD 2.95%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     2/50 (4%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/300 (1%)      Mean 1%      SD 1.67%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 104
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    1/50 (2%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/300 (0.67%)   Mean 0.67%   SD 1.03%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 105
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     3/50 (6%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/300 (1.67%)   Mean 1.67%   SD 2.66%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     3/50 (6%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/300 (2%)      Mean 2%      SD 2.53%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     3/50 (6%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 7/300 (2.33%)   Mean 2.33%   SD 2.34%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 106
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/49 (2%)     1/49 (2%)     3/50 (6%)           1/49 (2%)     0/48 (0%)     0/50 (0%)     |
|                                        2/48 (4%)     0/48 (0%)     1/50 (2%)           1/49 (2%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 8/294 (2.72%)   Mean 2.71%   SD 2.08%     Total 3/295 (1.02%)    Mean 1.02%   SD 1.12%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     1/48 (2%)     0/50 (0%)     |
|                                        0/48 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/294 (0%)      Mean 0%      SD 0%        Total 1/295 (0.34%)    Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/49 (2%)     1/49 (2%)     3/50 (6%)           1/49 (2%)     1/48 (2%)     0/50 (0%)     |
|                                        2/48 (4%)     0/48 (0%)     1/50 (2%)           1/49 (2%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 8/294 (2.72%)   Mean 2.71%   SD 2.08%     Total 4/295 (1.36%)    Mean 1.37%   SD 1.06%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/49 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.03%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/49 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/299 (1%)      Mean 1%      SD 1.67%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 107
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     3/50 (6%)     2/50 (4%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 9/300 (3%)      Mean 3%      SD 2.1%      Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              22/50 (44%)   22/50 (44%)   17/50 (34%)          7/49 (14%)   17/49 (35%)   12/50 (24%)    |
|                                       18/50 (36%)   23/50 (46%)   15/50 (30%)         14/49 (29%)    9/50 (18%)    6/50 (12%)    |
| Overall Incidence               Total 117/300 (39%)   Mean 39%     SD 6.54%     Total 65/297 (21.89%)  Mean 21.93%  SD 8.76%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            10/50 (20%)   13/50 (26%)   11/50 (22%)          4/49 (8%)     5/49 (10%)    6/50 (12%)    |
|                                        9/50 (18%)   16/50 (32%)   14/50 (28%)          4/49 (8%)     6/50 (12%)    6/50 (12%)    |
| Overall Incidence               Total 73/300 (24.33%) Mean 24.33%  SD 5.28%     Total 31/297 (10.44%)  Mean 10.42%  SD 1.88%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/50 (20%)   13/50 (26%)   11/50 (22%)          4/49 (8%)     5/49 (10%)    6/50 (12%)    |
|      Hepatoblastoma                    9/50 (18%)   16/50 (32%)   14/50 (28%)          4/49 (8%)     6/50 (12%)    6/50 (12%)    |
| Overall Incidence               Total 73/300 (24.33%) Mean 24.33%  SD 5.28%     Total 31/297 (10.44%)  Mean 10.42%  SD 1.88%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         28/50 (56%)   30/50 (60%)   26/50 (52%)         11/49 (22%)   19/49 (39%)   18/50 (36%)    |
|      Hepatocellular Adenoma           25/50 (50%)   34/50 (68%)   26/50 (52%)         18/49 (37%)   13/50 (26%)   12/50 (24%)    |
| Overall Incidence               Total 169/300 (56.33%)Mean 56.33%  SD 6.74%     Total 91/297 (30.64%)  Mean 30.66%  SD 7.28%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           28/50 (56%)   30/50 (60%)   26/50 (52%)         11/49 (22%)   19/49 (39%)   18/50 (36%)    |
|      Hepatocellular Adenoma, or       25/50 (50%)   34/50 (68%)   26/50 (52%)         18/49 (37%)   13/50 (26%)   12/50 (24%)    |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 169/300 (56.33%)Mean 56.33%  SD 6.74%     Total 91/297 (30.64%)  Mean 30.66%  SD 7.28%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/297 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 108
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         8/50 (16%)   12/49 (24%)   13/50 (26%)          1/49 (2%)     4/50 (8%)     3/50 (6%)     |
|                                       13/50 (26%)    6/50 (12%)   13/50 (26%)          2/50 (4%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 65/299 (21.74%) Mean 21.75%  SD 6.16%     Total 13/299 (4.35%)   Mean 4.34%   SD 2.33%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       8/50 (16%)    5/49 (10%)    6/50 (12%)          6/49 (12%)    2/50 (4%)     1/50 (2%)     |
|                                        6/50 (12%)    7/50 (14%)   12/50 (24%)          1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 44/299 (14.72%) Mean 14.7%   SD 4.97%     Total 10/299 (3.34%)   Mean 3.37%   SD 4.6%      |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   15/50 (30%)   16/49 (33%)   18/50 (36%)          7/49 (14%)    6/50 (12%)    4/50 (8%)     |
|      Alveolar/Bronchiolar Adenoma     17/50 (34%)   13/50 (26%)   22/50 (44%)          3/50 (6%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 101/299 (33.78%)Mean 33.78%  SD 6.09%     Total 23/299 (7.69%)   Mean 7.71%   SD 4.71%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 109
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 110
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|      or Adenoma                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/298 (0.34%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/298 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 111
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     1/50 (2%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     1/50 (2%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/300 (0.67%)   Mean 0.67%   SD 1.03%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/49 (2%)     3/48 (6%)     0/47 (0%)     |
|                                                                                        2/50 (4%)     1/49 (2%)     1/48 (2%)     |
| Overall Incidence                                                               Total 8/291 (2.75%)    Mean 2.74%   SD 2.14%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/49 (2%)     0/48 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 1/291 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/49 (2%)     0/48 (0%)     0/47 (0%)     |
|      Malignant, NOS                                                                    0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 1/291 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           1/49 (2%)     0/48 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/48 (0%)     |
| Overall Incidence                                                               Total 2/291 (0.69%)    Mean 0.68%   SD 1.05%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/48 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 0/291 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 112
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/49 (2%)     1/48 (2%)     0/47 (0%)     |
|                                                                                        2/50 (4%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 4/291 (1.37%)    Mean 1.35%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)     0/48 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/48 (0%)     |
| Overall Incidence                                                               Total 1/291 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)     0/48 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 0/291 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)     0/48 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 0/291 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/48 (2%)     0/48 (0%)     0/48 (0%)          13/49 (27%)    8/47 (17%)   10/50 (20%)    |
|   Adenoma                              0/43 (0%)     0/49 (0%)     1/50 (2%)           9/48 (19%)   10/47 (21%)    8/49 (16%)    |
| Overall Incidence               Total 2/286 (0.7%)    Mean 0.68%   SD 1.05%     Total 58/290 (20%)     Mean 19.98%  SD 3.69%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/48 (0%)     0/48 (0%)           0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|   Carcinoma                            0/43 (0%)     0/49 (0%)     1/50 (2%)           0/48 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/286 (0.35%)   Mean 0.33%   SD 0.82%     Total 0/290 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/48 (2%)     0/48 (0%)     0/48 (0%)          13/49 (27%)    8/47 (17%)   10/50 (20%)    |
|   Carcinoma or Adenoma                 0/43 (0%)     0/49 (0%)     2/50 (4%)           9/48 (19%)   10/47 (21%)    8/49 (16%)    |
| Overall Incidence               Total 3/286 (1.05%)   Mean 1.01%   SD 1.68%     Total 58/290 (20%)     Mean 19.98%  SD 3.69%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/48 (0%)     0/48 (0%)           1/49 (2%)     1/47 (2%)     0/50 (0%)     |
|                                        0/43 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/286 (0%)      Mean 0%      SD 0%        Total 2/290 (0.69%)    Mean 0.69%   SD 1.08%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 113
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     0/48 (0%)     0/48 (0%)           1/49 (2%)     1/47 (2%)     0/50 (0%)     |
|                                        0/43 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/286 (0%)      Mean 0%      SD 0%        Total 2/290 (0.69%)    Mean 0.69%   SD 1.08%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/48 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        1/49 (2%)     0/46 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/291 (0.34%)   Mean 0.34%   SD 0.83%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/48 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        1/49 (2%)     0/46 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/291 (0.34%)   Mean 0.34%   SD 0.83%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/48 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/291 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 114
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 115
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 4/299 (1.34%)    Mean 1.33%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 116
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     3/50 (6%)     0/50 (0%)           2/49 (4%)     1/50 (2%)     0/50 (0%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 4/300 (1.33%)   Mean 1.33%   SD 2.42%     Total 7/299 (2.34%)    Mean 2.35%   SD 1.52%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 117
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     3/50 (6%)     0/50 (0%)           2/49 (4%)     1/50 (2%)     0/50 (0%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 4/300 (1.33%)   Mean 1.33%   SD 2.42%     Total 7/299 (2.34%)    Mean 2.35%   SD 1.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     2/50 (4%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/300 (0.67%)   Mean 0.67%   SD 1.63%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           2/49 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 2/300 (0.67%)   Mean 0.67%   SD 1.03%     Total 7/299 (2.34%)    Mean 2.35%   SD 1.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/49 (0%)     1/49 (2%)     2/50 (4%)           1/49 (2%)     0/49 (0%)     1/50 (2%)     |
|                                        2/48 (4%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     1/49 (2%)     2/50 (4%)     |
| Overall Incidence               Total 5/295 (1.69%)   Mean 1.7%    SD 2.01%     Total 5/296 (1.69%)    Mean 1.68%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 118
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     1/50 (2%)     2/50 (4%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 5/300 (1.67%)   Mean 1.67%   SD 1.97%     Total 3/299 (1%)       Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     1/50 (2%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 4/300 (1.33%)   Mean 1.33%   SD 1.63%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     1/50 (2%)     2/50 (4%)                                                     |
|                                        2/50 (4%)     1/50 (2%)     0/50 (0%)                                                     |
| Overall Incidence               Total 6/300 (2%)      Mean 2%      SD 1.79%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 119
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|      Malignant, NOS                    0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/44 (0%)     0/44 (0%)     0/35 (0%)           0/48 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/40 (0%)     0/41 (0%)     0/35 (0%)           0/45 (0%)     0/43 (0%)     0/44 (0%)     |
| Overall Incidence               Total 0/239 (0%)      Mean 0%      SD 0%        Total 0/276 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/44 (0%)     0/44 (0%)     0/35 (0%)           0/48 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/40 (0%)     0/41 (0%)     0/35 (0%)           0/45 (0%)     0/43 (0%)     0/44 (0%)     |
| Overall Incidence               Total 0/239 (0%)      Mean 0%      SD 0%        Total 0/276 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/44 (0%)     0/44 (0%)     0/35 (0%)           0/48 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/40 (0%)     0/41 (0%)     0/35 (0%)           0/45 (0%)     0/43 (0%)     0/44 (0%)     |
| Overall Incidence               Total 0/239 (0%)      Mean 0%      SD 0%        Total 0/276 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/44 (0%)     0/44 (0%)     0/35 (0%)           0/48 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/40 (0%)     0/41 (0%)     0/35 (0%)           0/45 (0%)     0/43 (0%)     0/44 (0%)     |
| Overall Incidence               Total 0/239 (0%)      Mean 0%      SD 0%        Total 0/276 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/48 (0%)     0/49 (0%)     0/47 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/48 (0%)     0/49 (0%)     0/47 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 120
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/48 (0%)     0/49 (0%)     0/47 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/48 (0%)     0/49 (0%)     0/47 (0%)           1/49 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        1/48 (2%)     1/49 (2%)     0/48 (0%)           0/49 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 2/289 (0.69%)   Mean 0.69%   SD 1.06%     Total 3/297 (1.01%)    Mean 1.01%   SD 1.68%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/48 (0%)     0/49 (0%)     1/47 (2%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/289 (0.35%)   Mean 0.35%   SD 0.87%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/48 (0%)     0/49 (0%)     1/47 (2%)           1/49 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        1/48 (2%)     1/49 (2%)     0/48 (0%)           0/49 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 3/289 (1.04%)   Mean 1.04%   SD 1.14%     Total 3/297 (1.01%)    Mean 1.01%   SD 1.68%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 121
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        1/48 (2%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
| Overall Incidence               Total 2/294 (0.68%)   Mean 0.68%   SD 1.05%     Total 0/292 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/294 (0%)      Mean 0%      SD 0%        Total 0/292 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/294 (0%)      Mean 0%      SD 0%        Total 0/292 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        1/48 (2%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
| Overall Incidence               Total 2/294 (0.68%)   Mean 0.68%   SD 1.05%     Total 0/292 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/294 (0%)      Mean 0%      SD 0%        Total 0/292 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 122
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence                                                               Total 5/299 (1.67%)    Mean 1.67%   SD 1.97%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     3/50 (6%)     2/50 (4%)     |
| Overall Incidence                                                               Total 7/299 (2.34%)    Mean 2.33%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 123
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 125
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       27/50 (54%)                                     29/50 (58%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    29/50 (58%)                                     30/50 (60%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)                                     42/50 (84%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        4/50 (8%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     1/50 (2%)                                      13/50 (26%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)                                       0/50 (0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 126
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/50 (2%)                                       2/50 (4%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 127
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 128
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/43 (0%)                                       0/42 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/43 (0%)                                       0/42 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              5/50 (10%)                                      6/50 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 7/50 (14%)                                      7/50 (14%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 129
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 130
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 131
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              17/50 (34%)                                     13/50 (26%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            12/50 (24%)                                      6/50 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         12/50 (24%)                                      6/50 (12%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         27/50 (54%)                                     17/50 (34%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           27/50 (54%)                                     17/50 (34%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             5/50 (10%)                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 132
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         9/50 (18%)                                      4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       5/50 (10%)                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)                                      4/50 (8%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 133
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       1/50 (2%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 134
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 135
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/49 (0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)                                       7/50 (14%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)                                       7/50 (14%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 136
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 137
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)                                       0/50 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 138
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 139
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      1/50 (2%)                                       4/50 (8%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/50 (2%)                                       4/50 (8%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 1/50 (2%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 140
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       1/50 (2%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 141
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)                                                                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/42 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/42 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    1/42 (2%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      1/42 (2%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 142
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 143
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 144
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 145
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       54/100(54%)                                     52/100(52%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    40/100(40%)                                     55/100(55%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         71/100(71%)                                     78/100(78%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      6/100(6%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        6/100(6%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/100(1%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     8/100(8%)                                      32/100(32%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/100(0%)                                       0/100(0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 146
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/99 (3%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/99 (0%)                                       1/92 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/98 (1%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           2/98 (2%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            2/98 (2%)                                       0/90 (0%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/99 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               1/99 (1%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/99 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 147
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/100(0%)                                       0/99 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 148
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/84 (0%)                                       0/70 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/84 (0%)                                       0/70 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                             12/100(12%)                                     10/100(10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                12/100(12%)                                     12/100(12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 149
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 150
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/99 (1%)                                       2/87 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            2/99 (2%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 3/99 (3%)                                       2/87 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/99 (1%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            1/99 (1%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 151
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 2/99 (2%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      4/100(4%)                                       1/98 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       2/100(2%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              30/100(30%)                                     17/98 (17%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            19/100(19%)                                      6/98 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         21/100(21%)                                      6/98 (6%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         46/100(46%)                                     22/98 (22%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           47/100(47%)                                     22/98 (22%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/100(0%)                                       1/98 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 152
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        26/100(26%)                                      9/95 (9%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       8/100(8%)                                       2/95 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   30/100(30%)                                     11/95 (12%)                                |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 153
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/100(0%)                                       1/100(1%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 154
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          3/79 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          2/79 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 155
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        2/79 (3%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      1/79 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/79 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/83 (0%)                                      17/83 (20%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/83 (0%)                                       0/83 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/83 (0%)                                      17/83 (20%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 156
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/83 (0%)                                       1/83 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/83 (0%)                                       1/83 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/99 (0%)                                       1/94 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/99 (0%)                                       1/94 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/100(0%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/100(0%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 157
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/100(0%)                                       0/100(0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/100(0%)                                       0/100(0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/100(0%)                                       1/100(1%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/100(0%)                                       1/100(1%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/100(0%)                                       1/100(1%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 158
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/100(0%)                                       1/100(1%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/100(0%)                                       0/100(0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 159
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/100(0%)                                       4/100(4%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/100(0%)                                       4/100(4%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/100(0%)                                       2/100(2%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/100(0%)                                       2/100(2%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 160
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       4/100(4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/99 (0%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      2/99 (2%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/99 (0%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/99 (0%)                                       1/91 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/100(0%)                                       1/100(1%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 161
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/99 (1%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/99 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/99 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/99 (0%)                                                                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/99 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/69 (0%)                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/69 (0%)                                       1/78 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/69 (0%)                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/69 (0%)                                       1/78 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              1/99 (1%)                                       2/92 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 162
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 163
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 164
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 165
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       37/50 (74%)                                     27/50 (54%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    23/50 (46%)                                     17/50 (34%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)                                     39/50 (78%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/50 (8%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        5/50 (10%)                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)                                       4/50 (8%)                                 |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)                                       0/50 (0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 166
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              4/50 (8%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)                                       1/50 (2%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 167
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 168
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/48 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/48 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              7/50 (14%)                                      7/50 (14%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 9/50 (18%)                                      7/50 (14%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 169
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 170
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/50 (4%)                                       1/47 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/50 (4%)                                       1/47 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 171
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              23/50 (46%)                                     11/50 (22%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             8/50 (16%)                                      3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/50 (20%)                                      3/50 (6%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         31/50 (62%)                                     13/50 (26%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           31/50 (62%)                                     13/50 (26%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 172
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        11/50 (22%)                                      2/49 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       9/50 (18%)                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   19/50 (38%)                                      2/49 (4%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 173
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       1/50 (2%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 174
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 175
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/49 (0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       2/46 (4%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       0/46 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       2/46 (4%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 176
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)                                       2/46 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)                                       2/46 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 177
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         2/50 (4%)                                       0/50 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 178
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 179
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)                                       0/50 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)                                       0/50 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)                                       0/50 (0%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)                                       0/50 (0%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       1/50 (2%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       1/50 (2%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 180
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      2/49 (4%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           2/50 (4%)                                       2/50 (4%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              2/50 (4%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 181
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/50 (2%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)                                                                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/44 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/44 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/44 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/44 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 182
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 183
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 184
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 185
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       32/50 (64%)                                     15/50 (30%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    29/50 (58%)                                     21/50 (42%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         44/50 (88%)                                     31/50 (62%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)                                       7/50 (14%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)                                       0/50 (0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 186
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/49 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/49 (2%)                                       0/49 (0%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 187
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 188
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/44 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/44 (0%)                                       1/45 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              4/50 (8%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            2/50 (4%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 6/50 (12%)                                      4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 189
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 190
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/49 (6%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 3/49 (6%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 191
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/50 (4%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       3/50 (6%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              16/50 (32%)                                      9/49 (18%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            23/50 (46%)                                      8/49 (16%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         24/50 (48%)                                      8/49 (16%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         36/50 (72%)                                     16/49 (33%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           36/50 (72%)                                     16/49 (33%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 192
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        12/50 (24%)                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       7/50 (14%)                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   18/50 (36%)                                      2/50 (4%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 193
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       0/50 (0%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 194
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 195
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/49 (0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/49 (2%)                                       5/48 (10%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)                                       0/48 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/49 (2%)                                       5/48 (10%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 196
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 197
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)                                       0/50 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 198
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 199
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)                                       3/50 (6%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)                                       3/50 (6%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 200
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 201
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)                                                                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/42 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/42 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/42 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/42 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 202
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 203
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 204
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: SODIUM PHOSPHATE                         Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 205
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       23/50 (46%)   26/50 (52%)   30/60 (50%)         13/50 (26%)   18/50 (36%)   21/60 (35%)    |
|                                       25/50 (50%)                                     17/50 (34%)                                |
| Overall Incidence               Total 104/210 (49.52%)Mean 49.5%   SD 2.52%     Total 69/210 (32.86%)  Mean 32.75%  SD 4.57%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    20/50 (40%)   15/50 (30%)   26/60 (43%)         12/50 (24%)   20/50 (40%)   16/60 (27%)    |
|                                       14/50 (28%)                                      9/50 (18%)                                |
| Overall Incidence               Total 75/210 (35.71%) Mean 35.33%  SD 7.48%     Total 57/210 (27.14%)  Mean 27.17%  SD 9.29%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         32/50 (64%)   34/50 (68%)   45/60 (75%)         23/50 (46%)   29/50 (58%)   33/60 (55%)    |
|                                       31/50 (62%)                                     21/50 (42%)                                |
| Overall Incidence               Total 142/210 (67.62%)Mean 67.25%  SD 5.74%     Total 106/210 (50.48%) Mean 50.25%  SD 7.5%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     3/60 (5%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.42%   SD 0.83%     Total 4/210 (1.9%)     Mean 1.75%   SD 2.36%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      2/50 (4%)     1/50 (2%)     4/60 (7%)           2/50 (4%)     3/50 (6%)     0/60 (0%)     |
|                                        1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 8/210 (3.81%)   Mean 3.67%   SD 2.21%     Total 6/210 (2.86%)    Mean 3%      SD 2.58%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        2/50 (4%)     1/50 (2%)     5/60 (8%)           2/50 (4%)     3/50 (6%)     3/60 (5%)     |
|                                        1/50 (2%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 9/210 (4.29%)   Mean 4.08%   SD 2.99%     Total 10/210 (4.76%)   Mean 4.75%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/210 (1.43%)   Mean 1.42%   SD 0.96%     Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)     3/50 (6%)     3/60 (5%)           6/50 (12%)    7/50 (14%)    8/60 (13%)    |
|      Lymphocytic, Mixed, NOS, or       3/50 (6%)                                       3/50 (6%)                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 11/210 (5.24%)  Mean 5.25%   SD 0.96%     Total 24/210 (11.43%)  Mean 11.33%  SD 3.65%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      NOS                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 206
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     4/50 (8%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     1/59 (2%)     |
|                                        3/49 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 9/209 (4.31%)   Mean 4.36%   SD 3.48%     Total 1/209 (0.48%)    Mean 0.42%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/59 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 1/209 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/59 (0%)     |
|      Complex, Malignant, NOS           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 1/209 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/210 (0.95%)   Mean 1%      SD 1.15%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 207
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.42%   SD 0.83%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 208
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Astrocytoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 209
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.42%   SD 0.83%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/46 (0%)     0/44 (0%)     0/54 (0%)           0/49 (0%)     0/47 (0%)     0/54 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/193 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/46 (0%)     0/44 (0%)     0/54 (0%)           0/49 (0%)     0/47 (0%)     0/54 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/193 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              9/50 (18%)    4/50 (8%)     4/60 (7%)           3/50 (6%)     6/50 (12%)    4/60 (7%)     |
|                                        3/50 (6%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 20/210 (9.52%)  Mean 9.67%   SD 5.62%     Total 15/210 (7.14%)   Mean 7.17%   SD 3.42%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     1/50 (2%)     1/60 (2%)           1/50 (2%)     1/50 (2%)     1/60 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/210 (1.43%)   Mean 1.42%   SD 0.96%     Total 3/210 (1.43%)    Mean 1.42%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                10/50 (20%)    5/50 (10%)    5/60 (8%)           4/50 (8%)     7/50 (14%)    5/60 (8%)     |
|                                        3/50 (6%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 23/210 (10.95%) Mean 11.08%  SD 6.17%     Total 18/210 (8.57%)   Mean 8.58%   SD 4.11%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 210
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 211
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.42%   SD 0.83%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/210 (1.43%)   Mean 1.33%   SD 1.63%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/210 (1.43%)   Mean 1.33%   SD 1.63%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/210 (1.43%)   Mean 1.33%   SD 1.63%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 212
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.42%   SD 0.83%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/59 (0%)           0/50 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/59 (0%)           0/50 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/59 (0%)           0/50 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/58 (0%)           0/50 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/207 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/58 (0%)           0/50 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/208 (0.48%)   Mean 0.5%    SD 1%        Total 0/207 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/58 (0%)           0/50 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/208 (0.48%)   Mean 0.5%    SD 1%        Total 0/207 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/58 (0%)           0/50 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/207 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 213
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 3/210 (1.43%)   Mean 1.42%   SD 0.96%     Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.42%   SD 0.83%     Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               7/50 (14%)   17/50 (34%)   18/60 (30%)          3/50 (6%)     4/50 (8%)     7/60 (12%)    |
|                                       14/50 (28%)                                      6/49 (12%)                                |
| Overall Incidence               Total 56/210 (26.67%) Mean 26.5%   SD 8.7%      Total 20/209 (9.57%)   Mean 9.48%   SD 2.98%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             4/50 (8%)    10/50 (20%)   12/60 (20%)          2/50 (4%)     1/50 (2%)     2/60 (3%)     |
|                                        8/50 (16%)                                      3/49 (6%)                                 |
| Overall Incidence               Total 34/210 (16.19%) Mean 16%     SD 5.66%     Total 8/209 (3.83%)    Mean 3.86%   SD 1.72%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          4/50 (8%)    10/50 (20%)   13/60 (22%)          2/50 (4%)     1/50 (2%)     2/60 (3%)     |
|      Hepatoblastoma                    8/50 (16%)                                      3/49 (6%)                                 |
| Overall Incidence               Total 35/210 (16.67%) Mean 16.42%  SD 6.09%     Total 8/209 (3.83%)    Mean 3.86%   SD 1.72%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/50 (20%)   23/50 (46%)   27/60 (45%)          4/50 (8%)     5/50 (10%)    9/60 (15%)    |
|      Hepatocellular Adenoma           20/50 (40%)                                      8/49 (16%)                                |
| Overall Incidence               Total 80/210 (38.1%)  Mean 37.75%  SD 12.12%    Total 26/209 (12.44%)  Mean 12.33%  SD 3.97%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           10/50 (20%)   23/50 (46%)   28/60 (47%)          4/50 (8%)     5/50 (10%)    9/60 (15%)    |
|      Hepatocellular Adenoma, or       20/50 (40%)                                      8/49 (16%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 81/210 (38.57%) Mean 38.17%  SD 12.48%    Total 26/209 (12.44%)  Mean 12.33%  SD 3.97%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        2/50 (4%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/210 (0.95%)   Mean 1%      SD 2%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 214
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        11/50 (22%)    8/50 (16%)    9/60 (15%)          4/50 (8%)     0/50 (0%)     2/60 (3%)     |
|                                        6/50 (12%)                                      5/50 (10%)                                |
| Overall Incidence               Total 34/210 (16.19%) Mean 16.25%  SD 4.19%     Total 11/210 (5.24%)   Mean 5.33%   SD 4.52%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       6/50 (12%)    2/50 (4%)     5/60 (8%)           0/50 (0%)     3/50 (6%)     3/60 (5%)     |
|                                        2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 15/210 (7.14%)  Mean 7.08%   SD 3.86%     Total 7/210 (3.33%)    Mean 3.25%   SD 2.75%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)    9/50 (18%)   14/60 (23%)          4/50 (8%)     3/50 (6%)     5/60 (8%)     |
|      Alveolar/Bronchiolar Adenoma      8/50 (16%)                                      6/50 (12%)                                |
| Overall Incidence               Total 45/210 (21.43%) Mean 21.33%  SD 5.42%     Total 18/210 (8.57%)   Mean 8.58%   SD 2.5%      |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 215
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.42%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 2/210 (0.95%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 2/210 (0.95%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 216
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     1/50 (2%)     0/60 (0%)     |
|      or Adenoma                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 2/210 (0.95%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 217
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)     2/48 (4%)     1/59 (2%)     |
|                                                                                        3/48 (6%)                                 |
| Overall Incidence                                                               Total 6/205 (2.93%)    Mean 3.03%   SD 2.75%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     2/48 (4%)     0/59 (0%)     |
|                                                                                        1/48 (2%)                                 |
| Overall Incidence                                                               Total 3/205 (1.46%)    Mean 1.56%   SD 1.99%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     2/48 (4%)     0/59 (0%)     |
|      Malignant, NOS                                                                    1/48 (2%)                                 |
| Overall Incidence                                                               Total 3/205 (1.46%)    Mean 1.56%   SD 1.99%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)     0/48 (0%)     0/59 (0%)     |
|                                                                                        1/48 (2%)                                 |
| Overall Incidence                                                               Total 1/205 (0.49%)    Mean 0.52%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/48 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)                                 |
| Overall Incidence                                                               Total 0/205 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 218
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/48 (0%)     2/59 (3%)     |
|                                                                                        0/48 (0%)                                 |
| Overall Incidence                                                               Total 2/205 (0.98%)    Mean 0.85%   SD 1.69%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     0/48 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)                                 |
| Overall Incidence                                                               Total 0/205 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)     0/48 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)                                 |
| Overall Incidence                                                               Total 0/205 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/48 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)                                 |
| Overall Incidence                                                               Total 0/205 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/59 (0%)           0/50 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     0/59 (0%)           0/50 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/208 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/49 (0%)     1/53 (2%)           1/50 (2%)     5/49 (10%)    3/58 (5%)     |
|   Adenoma                              0/46 (0%)                                       0/45 (0%)                                 |
| Overall Incidence               Total 1/197 (0.51%)   Mean 0.47%   SD 0.94%     Total 9/202 (4.46%)    Mean 4.34%   SD 4.45%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/49 (0%)     0/53 (0%)           0/50 (0%)     0/49 (0%)     0/58 (0%)     |
|   Carcinoma                            0/46 (0%)                                       0/45 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/202 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/49 (0%)     1/53 (2%)           1/50 (2%)     5/49 (10%)    3/58 (5%)     |
|   Carcinoma or Adenoma                 0/46 (0%)                                       0/45 (0%)                                 |
| Overall Incidence               Total 1/197 (0.51%)   Mean 0.47%   SD 0.94%     Total 9/202 (4.46%)    Mean 4.34%   SD 4.45%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/49 (0%)     0/49 (0%)     0/53 (0%)           0/50 (0%)     0/49 (0%)     0/58 (0%)     |
|                                        0/46 (0%)                                       0/45 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/202 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 219
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/49 (0%)     0/49 (0%)     0/53 (0%)           0/50 (0%)     0/49 (0%)     0/58 (0%)     |
|                                        0/46 (0%)                                       0/45 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/202 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.42%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 220
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Tumor Benign, or                  0/50 (0%)                                       0/50 (0%)                                 |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)                                       0/50 (0%)                                 |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 221
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)                                       0/50 (0%)                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    1/50 (2%)                                       0/50 (0%)                                 |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     2/50 (4%)     0/60 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 4/210 (1.9%)     Mean 2%      SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 222
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Papilloma                         1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Papilloma, Squamous Cell          1/50 (2%)                                       0/50 (0%)                                 |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Papilloma, or Keratoacanthoma     1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     2/50 (4%)     1/60 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)                                       2/50 (4%)                                 |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 5/210 (2.38%)    Mean 2.42%   SD 1.95%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 223
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 2/210 (0.95%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     2/50 (4%)     1/60 (2%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)                                       2/50 (4%)                                 |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 5/210 (2.38%)    Mean 2.42%   SD 1.95%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      (malignant or NOS)                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)                                       0/50 (0%)                                 |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 3/210 (1.43%)    Mean 1.42%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     1/60 (2%)           0/50 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/209 (0.48%)   Mean 0.42%   SD 0.83%     Total 0/207 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)     0/49 (0%)     2/60 (3%)           0/50 (0%)     2/49 (4%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 3/209 (1.44%)   Mean 1.33%   SD 1.63%     Total 2/207 (0.97%)    Mean 1.02%   SD 2.04%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 224
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/207 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/207 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.42%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     1/50 (2%)     0/60 (0%)           2/50 (4%)     2/50 (4%)     1/60 (2%)     |
|      Papilloma Squamous                1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/210 (0.95%)   Mean 1%      SD 1.15%     Total 5/210 (2.38%)    Mean 2.42%   SD 1.95%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/60 (0%)           2/50 (4%)     2/50 (4%)     1/60 (2%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 5/210 (2.38%)    Mean 2.42%   SD 1.95%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 225
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              1/50 (2%)     0/50 (0%)     0/60 (0%)                                                     |
|      Malignant, NOS                    0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         1/50 (2%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/47 (0%)     0/48 (0%)     0/57 (0%)           0/50 (0%)     0/49 (0%)     0/57 (0%)     |
|                                        0/47 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/204 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/47 (0%)     0/48 (0%)     0/57 (0%)           0/50 (0%)     0/49 (0%)     0/57 (0%)     |
|                                        0/47 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/204 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/47 (0%)     0/48 (0%)     0/57 (0%)           0/50 (0%)     0/49 (0%)     0/57 (0%)     |
|                                        0/47 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/204 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/47 (0%)     0/48 (0%)     0/57 (0%)           0/50 (0%)     0/49 (0%)     0/57 (0%)     |
|                                        0/47 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/204 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 1/209 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 226
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     1/50 (2%)     1/59 (2%)           1/49 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/209 (0.96%)   Mean 0.92%   SD 1.07%     Total 1/209 (0.48%)    Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     1/59 (2%)           1/49 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/209 (0.96%)   Mean 0.92%   SD 1.07%     Total 1/209 (0.48%)    Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/210 (0.95%)   Mean 0.83%   SD 1.67%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/210 (0.48%)   Mean 0.5%    SD 1%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Papilloma Squamous                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 227
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/59 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/59 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/59 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/59 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/59 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/209 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 228
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/210 (0.48%)    Mean 0.42%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     0/50 (0%)     2/60 (3%)     |
|                                                                                        3/50 (6%)                                 |
| Overall Incidence                                                               Total 5/210 (2.38%)    Mean 2.33%   SD 2.91%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/50 (2%)     0/50 (0%)     2/60 (3%)     |
|                                                                                        3/50 (6%)                                 |
| Overall Incidence                                                               Total 6/210 (2.86%)    Mean 2.83%   SD 2.52%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 229
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/210 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 231
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       34/50 (68%)     0/0 (0%)    25/49 (51%)         38/50 (76%)   34/50 (68%)   29/50 (58%)    |
| Overall Incidence               Total 59/99 (59.6%)   Mean 39.67%  SD 35.39%    Total 101/150 (67.33%) Mean 67.33%  SD 9.02%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    29/50 (58%)     0/0 (0%)    23/49 (47%)         33/50 (66%)   43/50 (86%)   36/50 (72%)    |
| Overall Incidence               Total 52/99 (52.53%)  Mean 34.98%  SD 30.79%    Total 112/150 (74.67%) Mean 74.67%  SD 10.26%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)     0/0 (0%)    37/49 (76%)         47/50 (94%)   46/50 (92%)   42/50 (84%)    |
| Overall Incidence               Total 82/99 (82.83%)  Mean 55.17%  SD 48.32%    Total 135/150 (90%)    Mean 90%     SD 5.29%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)      0/0 (0%)     0/49 (0%)           2/50 (4%)     1/50 (2%)     3/50 (6%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 6/150 (4%)       Mean 4%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)      0/0 (0%)     4/49 (8%)           3/50 (6%)     8/50 (16%)    1/50 (2%)     |
| Overall Incidence               Total 5/99 (5.05%)    Mean 3.39%   SD 4.25%     Total 12/150 (8%)      Mean 8%      SD 7.21%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/50 (2%)      0/0 (0%)     4/49 (8%)           5/50 (10%)    8/50 (16%)    4/50 (8%)     |
| Overall Incidence               Total 5/99 (5.05%)    Mean 3.39%   SD 4.25%     Total 17/150 (11.33%)  Mean 11.33%  SD 4.16%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/99 (1.01%)    Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)      0/0 (0%)     0/49 (0%)          23/50 (46%)   29/50 (58%)   27/50 (54%)    |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 3/99 (3.03%)    Mean 2%      SD 3.46%     Total 79/150 (52.67%)  Mean 52.67%  SD 6.11%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                                                                                                                         |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 232
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/50 (6%)      0/0 (0%)     3/49 (6%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/99 (6.06%)    Mean 4.04%   SD 3.5%      Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)      0/0 (0%)     0/49 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)      0/0 (0%)     1/49 (2%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/98 (1.02%)    Mean 0.68%   SD 1.18%     Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)      0/0 (0%)     1/49 (2%)           3/50 (6%)     1/50 (2%)     1/50 (2%)     |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 1/98 (1.02%)    Mean 0.68%   SD 1.18%     Total 5/150 (3.33%)    Mean 3.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/49 (0%)      0/0 (0%)     0/47 (0%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/49 (0%)      0/0 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)      0/0 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 233
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 234
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)      0/0 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/44 (0%)      0/0 (0%)     0/39 (0%)           0/40 (0%)     0/46 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 0/133 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/44 (0%)      0/0 (0%)     0/39 (0%)           0/40 (0%)     0/46 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/83 (0%)       Mean 0%      SD 0%        Total 0/133 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              6/50 (12%)     0/0 (0%)     3/49 (6%)          11/50 (22%)    3/50 (6%)     9/50 (18%)    |
| Overall Incidence               Total 9/99 (9.09%)    Mean 6.04%   SD 6%        Total 23/150 (15.33%)  Mean 15.33%  SD 8.33%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)      0/0 (0%)     0/49 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 6/50 (12%)     0/0 (0%)     3/49 (6%)          12/50 (24%)    4/50 (8%)    10/50 (20%)    |
| Overall Incidence               Total 9/99 (9.09%)    Mean 6.04%   SD 6%        Total 26/150 (17.33%)  Mean 17.33%  SD 8.33%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)      0/0 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)      0/0 (0%)     1/49 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/99 (1.01%)    Mean 0.68%   SD 1.18%     Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 235
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)      0/0 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              1/50 (2%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/99 (1.01%)    Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 236
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            2/50 (4%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/99 (2.02%)    Mean 1.33%   SD 2.31%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)      0/0 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/99 (1.01%)    Mean 0.68%   SD 1.18%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              1/50 (2%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/99 (1.01%)    Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            2/50 (4%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/99 (2.02%)    Mean 1.33%   SD 2.31%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 3/50 (6%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/99 (3.03%)    Mean 2%      SD 3.46%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)      0/0 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/99 (1.01%)    Mean 0.68%   SD 1.18%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/48 (2%)      0/0 (0%)     0/46 (0%)           0/46 (0%)     3/49 (6%)     1/49 (2%)     |
| Overall Incidence               Total 1/94 (1.06%)    Mean 0.69%   SD 1.2%      Total 4/144 (2.78%)    Mean 2.72%   SD 3.12%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/48 (0%)      0/0 (0%)     0/46 (0%)           0/46 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/94 (0%)       Mean 0%      SD 0%        Total 0/144 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/48 (2%)      0/0 (0%)     0/46 (0%)           0/46 (0%)     3/49 (6%)     1/49 (2%)     |
| Overall Incidence               Total 1/94 (1.06%)    Mean 0.69%   SD 1.2%      Total 4/144 (2.78%)    Mean 2.72%   SD 3.12%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/49 (0%)      0/0 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/98 (1.02%)    Mean 0.68%   SD 1.18%     Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/49 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 237
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/49 (0%)      0/0 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/98 (1.02%)    Mean 0.68%   SD 1.18%     Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/49 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   1/48 (2%)      0/0 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/97 (1.03%)    Mean 0.69%   SD 1.2%      Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/48 (0%)      0/0 (0%)     0/49 (0%)           2/49 (4%)     0/50 (0%)     1/49 (2%)     |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 3/148 (2.03%)    Mean 2.04%   SD 2.04%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/48 (2%)      0/0 (0%)     1/49 (2%)           1/49 (2%)     2/50 (4%)     1/49 (2%)     |
| Overall Incidence               Total 2/97 (2.06%)    Mean 1.37%   SD 1.19%     Total 4/148 (2.7%)     Mean 2.69%   SD 1.13%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       6/48 (13%)     0/0 (0%)     0/49 (0%)           1/49 (2%)     1/50 (2%)     1/49 (2%)     |
| Overall Incidence               Total 6/97 (6.19%)    Mean 4.17%   SD 7.22%     Total 3/148 (2.03%)    Mean 2.03%   SD 0.02%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              30/48 (63%)     0/0 (0%)    18/49 (37%)         30/49 (61%)   24/50 (48%)   19/49 (39%)    |
| Overall Incidence               Total 48/97 (49.48%)  Mean 33.08%  SD 31.41%    Total 73/148 (49.32%)  Mean 49.33%  SD 11.28%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            20/48 (42%)     0/0 (0%)    14/49 (29%)          3/49 (6%)    13/50 (26%)    3/49 (6%)     |
| Overall Incidence               Total 34/97 (35.05%)  Mean 23.41%  SD 21.31%    Total 19/148 (12.84%)  Mean 12.75%  SD 11.48%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         23/48 (48%)     0/0 (0%)    14/49 (29%)          4/49 (8%)    14/50 (28%)    4/49 (8%)     |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 37/97 (38.14%)  Mean 25.5%   SD 24.11%    Total 22/148 (14.86%)  Mean 14.78%  SD 11.45%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         41/48 (85%)     0/0 (0%)    28/49 (57%)         31/49 (63%)   30/50 (60%)   22/49 (45%)    |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 69/97 (71.13%)  Mean 47.52%  SD 43.51%    Total 83/148 (56.08%)  Mean 56.05%  SD 9.8%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           41/48 (85%)     0/0 (0%)    28/49 (57%)         31/49 (63%)   31/50 (62%)   22/49 (45%)    |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 69/97 (71.13%)  Mean 47.52%  SD 43.51%    Total 84/148 (56.76%)  Mean 56.72%  SD 10.26%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/48 (0%)      0/0 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 238
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/48 (0%)      0/0 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     1/49 (2%)     |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 1/148 (0.68%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)      0/0 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/99 (1.01%)    Mean 0.68%   SD 1.18%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         6/50 (12%)     0/0 (0%)     7/49 (14%)          3/50 (6%)     6/50 (12%)    1/50 (2%)     |
| Overall Incidence               Total 13/99 (13.13%)  Mean 8.76%   SD 7.67%     Total 10/150 (6.67%)   Mean 6.67%   SD 5.03%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       4/50 (8%)      0/0 (0%)     5/49 (10%)          1/50 (2%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 9/99 (9.09%)    Mean 6.07%   SD 5.37%     Total 3/150 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   10/50 (20%)     0/0 (0%)    12/49 (24%)          4/50 (8%)     6/50 (12%)    2/50 (4%)     |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 22/99 (22.22%)  Mean 14.83%  SD 13.04%    Total 12/150 (8%)      Mean 8%      SD 4%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 239
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)      0/0 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 240
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       1/50 (2%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/99 (1.01%)    Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)      0/0 (0%)     0/48 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)      0/0 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)      0/0 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)      0/0 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)      0/0 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)      0/0 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/45 (2%)     4/50 (8%)     0/49 (0%)     |
| Overall Incidence                                                               Total 5/144 (3.47%)    Mean 3.41%   SD 4.13%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/45 (2%)     1/50 (2%)     0/49 (0%)     |
| Overall Incidence                                                               Total 2/144 (1.39%)    Mean 1.41%   SD 1.22%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 241
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/45 (2%)     1/50 (2%)     0/49 (0%)     |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 2/144 (1.39%)    Mean 1.41%   SD 1.22%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/45 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/144 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/45 (0%)     2/50 (4%)     0/49 (0%)     |
| Overall Incidence                                                               Total 2/144 (1.39%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              3/45 (7%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 3/144 (2.08%)    Mean 2.22%   SD 3.85%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/45 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/144 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/45 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/144 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/45 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/144 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/48 (0%)      0/0 (0%)     0/46 (0%)           0/46 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/94 (0%)       Mean 0%      SD 0%        Total 0/145 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/48 (0%)      0/0 (0%)     0/46 (0%)           0/46 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/94 (0%)       Mean 0%      SD 0%        Total 0/145 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)      0/0 (0%)     0/45 (0%)           3/46 (7%)     3/49 (6%)     2/47 (4%)     |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 8/142 (5.63%)    Mean 5.63%   SD 1.21%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)      0/0 (0%)     0/45 (0%)           0/46 (0%)     0/49 (0%)     0/47 (0%)     |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 0/142 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)      0/0 (0%)     0/45 (0%)           3/46 (7%)     3/49 (6%)     2/47 (4%)     |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 8/142 (5.63%)    Mean 5.63%   SD 1.21%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 242
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/47 (0%)      0/0 (0%)     0/45 (0%)           0/46 (0%)     2/49 (4%)     1/47 (2%)     |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 3/142 (2.11%)    Mean 2.07%   SD 2.04%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/47 (0%)      0/0 (0%)     0/45 (0%)           0/46 (0%)     2/49 (4%)     1/47 (2%)     |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 3/142 (2.11%)    Mean 2.07%   SD 2.04%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)      0/0 (0%)     0/48 (0%)                                                     |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)      0/0 (0%)     0/48 (0%)                                                     |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)      0/0 (0%)     0/48 (0%)                                                     |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)      0/0 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)      0/0 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)      0/0 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 243
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 244
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     4/50 (8%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 4/150 (2.67%)    Mean 2.67%   SD 4.62%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 245
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)      0/0 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/99 (1.01%)    Mean 0.68%   SD 1.18%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)      0/0 (0%)     1/49 (2%)           0/50 (0%)     5/50 (10%)    4/50 (8%)     |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/99 (1.01%)    Mean 0.68%   SD 1.18%     Total 9/150 (6%)       Mean 6%      SD 5.29%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     5/50 (10%)    4/50 (8%)     |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 9/150 (6%)       Mean 6%      SD 5.29%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)      0/0 (0%)     0/49 (0%)           3/50 (6%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)      0/0 (0%)     0/49 (0%)           3/50 (6%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 246
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     4/50 (8%)     1/50 (2%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 5/150 (3.33%)    Mean 3.33%   SD 4.16%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)      0/0 (0%)     0/49 (0%)           3/50 (6%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/48 (0%)      0/0 (0%)     0/47 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/95 (0%)       Mean 0%      SD 0%        Total 1/149 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/48 (0%)      0/0 (0%)     2/47 (4%)           2/49 (4%)     4/50 (8%)     0/50 (0%)     |
| Overall Incidence               Total 2/95 (2.11%)    Mean 1.42%   SD 2.46%     Total 6/149 (4.03%)    Mean 4.03%   SD 4%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/48 (0%)      0/0 (0%)     0/47 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/95 (0%)       Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/48 (0%)      0/0 (0%)     0/47 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/95 (0%)       Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)      0/0 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/99 (1.01%)    Mean 0.68%   SD 1.18%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)      0/0 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 1/99 (1.01%)    Mean 0.68%   SD 1.18%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 247
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)      0/0 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)      0/0 (0%)     1/49 (2%)                                                     |
| Overall Incidence               Total 1/99 (1.01%)    Mean 0.68%   SD 1.18%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)      0/0 (0%)     0/49 (0%)                                                     |
|      Malignant, NOS                                                                                                              |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)      0/0 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/43 (0%)      0/0 (0%)     0/42 (0%)           0/48 (0%)     0/49 (0%)     0/44 (0%)     |
| Overall Incidence               Total 0/85 (0%)       Mean 0%      SD 0%        Total 0/141 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/43 (0%)      0/0 (0%)     0/42 (0%)           0/48 (0%)     0/49 (0%)     0/44 (0%)     |
| Overall Incidence               Total 0/85 (0%)       Mean 0%      SD 0%        Total 0/141 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/43 (0%)      0/0 (0%)     0/42 (0%)           0/48 (0%)     1/49 (2%)     0/44 (0%)     |
| Overall Incidence               Total 0/85 (0%)       Mean 0%      SD 0%        Total 1/141 (0.71%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/43 (0%)      0/0 (0%)     0/42 (0%)           0/48 (0%)     1/49 (2%)     0/44 (0%)     |
| Overall Incidence               Total 0/85 (0%)       Mean 0%      SD 0%        Total 1/141 (0.71%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/48 (0%)      0/0 (0%)     0/48 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/48 (0%)      0/0 (0%)     0/48 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/48 (0%)      0/0 (0%)     0/48 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/48 (0%)      0/0 (0%)     0/48 (0%)           1/48 (2%)     2/50 (4%)     3/50 (6%)     |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 6/148 (4.05%)    Mean 4.03%   SD 1.96%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 248
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/48 (0%)      0/0 (0%)     0/48 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/48 (0%)      0/0 (0%)     0/48 (0%)           1/48 (2%)     2/50 (4%)     3/50 (6%)     |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 6/148 (4.05%)    Mean 4.03%   SD 1.96%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)      0/0 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/49 (0%)      0/0 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/49 (0%)      0/0 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 249
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)      0/0 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/49 (0%)      0/0 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/50 (2%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence                                                               Total 4/150 (2.67%)    Mean 2.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 250
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)      0/0 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 251
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       29/50 (58%)                                     35/50 (70%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    27/50 (54%)                                     26/50 (52%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         42/50 (84%)                                     47/50 (94%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/50 (2%)                                       6/50 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)                                      10/50 (20%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)                                       0/50 (0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 252
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              5/50 (10%)                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)                                       0/49 (0%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 253
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/49 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 254
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/45 (0%)                                       0/42 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/45 (0%)                                       0/42 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              9/50 (18%)                                      9/50 (18%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                10/50 (20%)                                     10/50 (20%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 255
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 256
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 257
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              18/50 (36%)                                     21/50 (42%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            20/50 (40%)                                     10/50 (20%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         20/50 (40%)                                     10/50 (20%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         35/50 (70%)                                     29/50 (58%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           35/50 (70%)                                     29/50 (58%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 258
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         6/50 (12%)                                      4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    8/50 (16%)                                      4/50 (8%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 259
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    1/50 (2%)                                       1/50 (2%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 260
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 261
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/49 (2%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       4/48 (8%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       1/48 (2%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       5/48 (10%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 262
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              1/50 (2%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 263
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)                                       0/50 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 264
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 265
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      1/50 (2%)                                       1/50 (2%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)                                       1/50 (2%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 266
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)                                       1/50 (2%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 267
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)                                                                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/47 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/47 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/47 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/47 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/49 (0%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 268
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/49 (0%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 269
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 270
 Version: 02/10/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: SKIN APPLICATION                           Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 28-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
