Alimentary System
Stomach, Forestomach - Mineralization
Narrative
Comment:
Mineralization of the forestomach usually involves the submucosa, often along the basement membrane (Figure 1), and tunica muscularis (Figure 2). Microscopically, mineralization appears as distinct, crystalline, basophilic material in the tissue. Mineralization in the forestomach usually results from altered calcium-phosphorus metabolism and hyperparathyroidism associated with uremia secondary to end-stage chronic progressive nephropathy.
Recommendations:
Mineralization should be diagnosed and graded based on the extent of the mineralization.
References:
Brown HR, Hardisty JF. 1990. Oral cavity, esophagus and stomach. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 9-30.
Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563Leininger JR, Jokinen MP, Dangler CA, Whiteley LO. 1999. Oral cavity, esophagus, and stomach. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 29-48.
Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Stomach, Forestomach - Mineralization in a male B6C3F1 mouse from a chronic study. Mineralization (arrow) is present along the basement membrane of the forestomach.
All Images
Stomach, Forestomach - Mineralization in a male B6C3F1 mouse from a chronic study. Mineralization (arrow) is present along the basement membrane of the forestomach.
Stomach, Forestomach - Mineralization in a male F344/N rat from a chronic study. Mineralization (arrow) of tunica muscularis of forestomach is present.