Reproductive System, Female

Oviduct - Necrosis

Narrative
Comment:

Oviduct necrosis is rarely seen in rodent studies. It may be a result of an associated inflammatory change in the adjacent ovary or uterus. Oviduct necrosis is characterized by hypereosinophilic, dissociated, fragmented, and sloughed epithelial cells (Figure 1 and Figure 2). Nuclei are pyknotic and karyorrhectic. It is usually accompanied by an inflammatory infiltrate.

Recommendations:

Oviduct - Necrosis should be diagnosed and graded whenever present. Secondary lesions such as inflammation or hemorrhage should not be diagnosed unless warranted by severity. If the necrosis is secondary to another lesion, such as inflammation, it should not be diagnosed unless warranted by severity.

References:

National Toxicology Program. 2006. NTP TR-521. Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies). NTP, Research Triangle Park, NC.

Abstract: https://ntp.niehs.nih.gov/go/9303

National Toxicology Program. 2006. NTP TR-526. Toxicology and Carcinogenesis Studies of a Mixture of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6), 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CAS No. 57117-31-4), and 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CAS No. 57465-28-8) in Female Harlan Sprague-Dawley Rats (Gavage Studies). NTP, Research Triangle Park, NC.

Abstract: https://ntp.niehs.nih.gov/go/9307
  • Image of necrosis in the oviduct from a female Harlan Sprague-Dawley rat in a chronic study

    Oviduct - Necrosis in a female Harlan Sprague-Dawley rat from a chronic study. There is sloughing of necrotic epithelial cells into the lumen of the oviduct.

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Oviduct - Necrosis in a female Harlan Sprague-Dawley rat from a chronic study. There is sloughing of necrotic epithelial cells into the lumen of the oviduct.
Oviduct - Necrosis in a female Harlan Sprague-Dawley rat from a chronic study. There is sloughing of necrotic epithelial cells into the lumen of the oviduct.
Oviduct - Necrosis in a female Harlan Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). There is sloughing of necrotic epithelial cells into the lumen of the oviduct.
Oviduct - Necrosis in a female Harlan Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). There is sloughing of necrotic epithelial cells into the lumen of the oviduct.

Authors

Gabrielle Willson, BVMS, Dip RC Path, FRC Path, MRCVS
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Karen Y. Cimon, DVM, MS
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Reviewers

Karen S. Regan, DVM, DABT, DACVP
Pathologist
Regan Path/Tox Services, Inc.
Ashland, OH  

Darlene Dixon, DVM, PhD, DACVP, Fellow, IATP
Group Leader, Molecular Pathogenesis Group
National Toxicology Program Laboratory
National Toxicology Program
National Institute of Environmental Health Sciences, Research Triangle Park, NC