Reproductive System, Male

Prostate - Edema

Narrative
Comment:
Edema is not a common finding in the prostate and may be related to interruption of vascular drainage. The interstitium is expanded by lightly staining eosinophilic and delicate wispy material. When present, a search for an apparent cause is appropriate. Inflammatory cytokines, substance P, and cytotoxic inflammatory factor type 1-positive E. coli have been associated with prostate edema in rats. Sporadic cases of prostate edema have been documented in NTP rat and mouse studies.
Recommendations:
When present, edema should be diagnosed and graded. Because it is interstitial, one or more lobes may be affected, and a lobe qualifier may not be needed.
References:

Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. 2012. Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22949412

Rippere-Lampe KE, Lang M, Ceri H, Olson M, Lockman HA, O'Brien AD. 2001. Cytotoxic necrotizing factor type 1-positive Escherichia coli causes increased inflammation and tissue damage to the prostate in a rat prostatitis model. Infect Immun 69:6515-6519.

Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC98788/

Vera PL, Meyer-Siegler KL. 2004. Inflammation of the rat prostate evokes release of macrophage migration inhibitory factor in the bladder: Evidence for a viscerovisceral reflex. J Urol 172:2440-2445.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/15538287
  • Image of edema in the prostate from a male F344/N rat in a chronic study

    Prostate - Edema. Edema of the prostate from a male F344/N rat in a chronic study.

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Prostate - Edema. Edema of the prostate from a male F344/N rat in a chronic study.
Prostate - Edema. Edema of the prostate from a male F344/N rat in a chronic study.
Prostate - Edema. Higher magnification of Figure 1. Edema of the prostate from a male F344/N rat in a chronic study.
Prostate - Edema. Higher magnification of Figure 1. Edema of the prostate from a male F344/N rat in a chronic study.

Authors:

Dianne M. Creasy, PhD, Dip RCPath, FRCPath
Dianne Creasy Consulting LLC
Pipersville, PA

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Dipak K. Giri, DVM, PHD, DACVP
Toxicologic Pathologist
Integrated Laboratory Systems, Inc.
Research Triangle Park, NC
 

Reviewers:

Mark F. Cesta, DVM, PhD, DACVP
Staff Scientist, NTP Pathologist
Cellular and Molecular Pathology Branch
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC
 

David E. Malarkey DVM, PhD, DACVP, FIATP
Head, National Toxicology Program Pathology Group
Cellular and Molecular Pathology Branch
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC