Special Senses System

Eye, Anterior Chamber - Proteinaceous Fluid

Narrative
Comment:
Anterior chamber proteinaceous fluid is characterized by intracameral accumulations of homogeneous pale eosinophilic material (often including fibrin) that contains few if any inflammatory cells (Figure 1 and Figure 2). Anterior chamber proteinaceous fluid can compress the iridocorneal filtration angle channels and/or the adjacent trabecular meshwork, impeding normal drainage of aqueous humor with resultant elevations in intraocular pressure. (Other ocular lesions in Figure 1 and/or Figure 2 include posterior synechiae, lens cataract with mineralization, and/or iridial inflammation.)
Recommendations:
Proteinaceous fluid in the anterior chamber should be diagnosed as "Eye, Anterior chamber - Proteinaceous fluid" and assigned a severity grade. If anterior chamber proteinaceous fluid is part of a more dispersed inflammatory process in the eye, it need not be diagnosed separately but should be described in the pathology narrative.
References:

National Toxicology Program. 1997. NTP TR-450. Toxicology and Carcinogenesis Studies of Tetrafluoroethylene (CAS No. 116-14-3) in F344 Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC.

Abstract: https://ntp.niehs.nih.gov/go/6044

Smith RS, Sundberg JP, John SWM. 2002. The anterior segment. In: Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods (Smith RS, John SWM, Nishina PM, Sundberg JP, eds). CRC Press, Boca Raton, FL, 111-159.

  • Image of anterior chamber proteinaceous fluid in the eye from a female F344/N rat in a chronic study

    Eye, Anterior chamber - Proteinaceous fluid in a female F344/N rat from a chronic study. Anterior chamber proteinaceous fluid (arrow) is characterized by accumulations of homogeneous pale eosinophilic material that contains few if any inflammatory cells.

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Eye, Anterior chamber - Proteinaceous fluid in a female F344/N rat from a chronic study. Anterior chamber proteinaceous fluid (arrow) is characterized by accumulations of homogeneous pale eosinophilic material that contains few if any inflammatory cells.
Eye, Anterior chamber - Proteinaceous fluid in a female F344/N rat from a chronic study. Anterior chamber proteinaceous fluid (arrow) is characterized by accumulations of homogeneous pale eosinophilic material that contains few if any inflammatory cells.
Eye, Anterior chamber - Proteinaceous fluid in a female F344/N rat from a chronic study. There are accumulations of homogeneous pale eosinophilic material in the anterior chamber (arrow) that contains few if any inflammatory cells.
Eye, Anterior chamber - Proteinaceous fluid in a female F344/N rat from a chronic study. There are accumulations of homogeneous pale eosinophilic material in the anterior chamber (arrow) that contains few if any inflammatory cells.

Author

Margarita M. Gruebbel, DVM, PhD, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Reviewers

Ruth E. Hurley, DVM, PHD, DACVP
Senior Veterinary Pathologist
Huntingdon Life Sciences
North Brunswick, NJ

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC