Urinary System

Urinary Bladder - Hemorrhage

Narrative

Comment:

Hemorrhage can be seen anywhere in the bladder. It is commonly associated with inflammation, calculi, or the presence of tumors (Figure 1 and Figure 2). Perimortem hemorrhage can be differentiated by the lack of any concurrent lesions, such as edema, inflammation, or hemosiderin.

Recommendations:

Hemorrhage is usually a secondary finding and should not be diagnosed unless it is a major component of the overall lesion and important in the pathogenesis of the lesion. Perimortem hemorrhage should not be diagnosed.

References:

Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735

All Images

Hemorrhage associated with inflammation, from a female F344/N rat in a chronic study.

Hemorrhage of undetermined pathogenesis from a male F344/N rat in a chronic study.

Authors and Reviewers

Authors

John Curtis Seely, DVM, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Abraham Nyska,  DVM, Diplomate ECVP, Fellow IATP
Expert in Toxicologic Pathology
Visiting Full Professor of Pathology
Sackler School of Medicine, Tel Aviv University
Timrat Israel

Reviewers

Samuel M Cohen, PHD, MD
Professor
Havlik-Wall Professor of Oncology
Director of Pathology Residency Program
Nebraska Medical Center
Omaha, NE

David E. Malarkey DVM, PhD, DACVP, FIATP
Head, National Toxicology Program Pathology Group
Cellular and Molecular Pathology Branch
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC