Reproductive System, Male

Penis, Epithelium - Hyperplasia

Narrative

Comment:

Hyperplasia of the mucosa is characterized by proliferation of squamous epithelium in the form of papillary folds (arrow, Figure 1). It is an uncommon incidental finding and is unlikely to be associated with chemical administration.

Recommendations:

This lesion should be diagnosed and given a severity grade.

References:

References not listed.

All Images

Penis, Epithelium - Hyperplasia. Arrow indicates papillary proliferation of squamous epithelium in a male B6C3F1 mouse from a chronic study.

Penis, Epithelium - Hyperplasia. Higher magnification of Figure 1 showing the hyperplastic squamous epithelium in a male B6C3F1 mouse from a chronic study.

Authors and Reviewers

Authors

Dianne M. Creasy, PhD, Dip RCPath, FRCPath
Dianne Creasy Consulting LLC
Pipersville, PA

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Dipak K. Giri, DVM, PHD, DACVP
Toxicologic Pathologist
Integrated Laboratory Systems, Inc.
Research Triangle Park, NC

Reviewers

Mark F. Cesta, DVM, PhD, DACVP
Staff Scientist, NTP Pathologist
Cellular and Molecular Pathology Branch
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC

David E. Malarkey DVM, PhD, DACVP, FIATP
Head, National Toxicology Program Pathology Group
Cellular and Molecular Pathology Branch
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC