Reproductive System, Male

Seminal Vesicle - Dilation

Narrative
Comment:
Dilation of seminal vesicles consists of distension of the gland with secretory material (Figure 1 and Figure 2). The epithelial cells and the papillary folds are flattened and reduced (arrows, Figure 1 and Figure 2). Dilation may be associated with obstruction and may lead to inspissation. Seminal vesicle dilation is usually associated with older age.
Recommendations:
Dilation should be recorded and graded. If both seminal vesicles are involved, the diagnosis should be qualified as bilateral and the severity grade determined by the more severely affect seminal vesicle.
References:

Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. 2012. Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22949412

Radovsky A, Mitsumori K, Chapin RE. 1999. Male reproductive tract. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 381-407.

Abstract: http://www.cacheriverpress.com/books/pathmouse.htm

Suwa T, Nyska A, Peckham JC, Hailey JR, Mahler JF, Haseman JK, Maronpot RR. 2001. A retrospective analysis of background lesions and tissue accountability for male accessory sex organs in Fischer-344 rats. Toxicol Pathol 29(4):467-478.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11560252

Suwa T, Nyska A, Haseman JK, Mahler JF, Maronpot RR. 2002. Spontaneous lesions in control B6C3F1 mice and recommended sectioning of male accessory sex organs. Toxicol Pathol 30(2):228-234.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11950166
  • Image of dilation in the seminal vesicle from a male F344/N rat in an chronic study

    Seminal Vesicle - Dilation. Arrows indicate flattened epithelium in the distended acinus in a male F344/N rat from a chronic study.

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Seminal Vesicle - Dilation. Arrows indicate flattened epithelium in the distended acinus in a male F344/N rat from a chronic study.
Seminal Vesicle - Dilation. Arrows indicate flattened epithelium in the distended acinus in a male F344/N rat from a chronic study.
Seminal Vesicle - Dilation. Arrows indicate flattened epithelium in the distended acinus in a male F344/N rat from a chronic study.
Seminal Vesicle - Dilation. Arrows indicate flattened epithelium in the distended acinus in a male F344/N rat from a chronic study.

Authors

Dianne M. Creasy, PhD, Dip RCPath, FRCPath
Dianne Creasy Consulting LLC
Pipersville, PA

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Dipak K. Giri, DVM, PHD, DACVP
Toxicologic Pathologist
Integrated Laboratory Systems, Inc.
Research Triangle Park, NC

Reviewers

Mark F. Cesta, DVM, PhD, DACVP
Staff Scientist, NTP Pathologist
Cellular and Molecular Pathology Branch
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC

David E. Malarkey DVM, PhD, DACVP, FIATP
Head, National Toxicology Program Pathology Group
Cellular and Molecular Pathology Branch
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC