Special Senses System

Lacrimal Gland - Infiltration Cellular, Mononuclear Cell

Narrative
Comment:
Scattered, variably sized interstitial foci of mononuclear cells (usually lymphocytes) are common in the lacrimal glands of rats and mice (Figure 1 and Figure 2), often increasing in incidence and severity in older animals. Increased incidences and severity of such infiltrates can also occur as treatment-related toxic effects or in other pathologic conditions.
Recommendations:
Lacrimal gland mononuclear cell infiltrates should be diagnosed and assigned a severity grade only if there are treatment-related differences in the incidence and/or severity. Mononuclear cell infiltrates can be distinguished from inflammation by features of inflammation such as tissue destruction, hemorrhage, fibrosis, edema, and the presence of other leukocyte types.
Related Links:
Lacrimal Gland - Inflammation
References:

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Full Text: https://doi.org/10.1167/iovs.08-1949

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  • Image of infiltration cellular, mononuclear cell in the lacrimal gland from a male B6C3F1 mouse in a chronic study

    Lacrimal gland - Infiltration cellular, Mononuclear cell in a male B6C3F1 mouse from a chronic study. Variably sized interstitial foci of mononuclear cells (mainly lymphocytes) (arrow) are present in the lacrimal gland.

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Lacrimal gland - Infiltration cellular, Mononuclear cell in a male B6C3F1 mouse from a chronic study. Variably sized interstitial foci of mononuclear cells (mainly lymphocytes) (arrow) are present in the lacrimal gland.
Lacrimal gland - Infiltration cellular, Mononuclear cell in a male B6C3F1 mouse from a chronic study. Variably sized interstitial foci of mononuclear cells (mainly lymphocytes) (arrow) are present in the lacrimal gland.
Lacrimal gland - Infiltration cellular, Mononuclear cell in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 1). The mononuclear cells (mainly lymphocytes) are present without evidence of tissue damage.
Lacrimal gland - Infiltration cellular, Mononuclear cell in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 1). The mononuclear cells (mainly lymphocytes) are present without evidence of tissue damage.

Author

Margarita M. Gruebbel, DVM, PhD, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Reviewers

Ruth E. Hurley, DVM, PHD, DACVP
Senior Veterinary Pathologist
Huntingdon Life Sciences
North Brunswick, NJ

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC