Alimentary System

Stomach, Glandular Stomach - Metaplasia, Squamous

Narrative
Comment:
Squamous metaplasia of the glandular stomach is characterized by a reversible change in which cuboidal or columnar mucosal epithelial cells are replaced by squamous epithelial cells (Figure 1 and Figure 2, arrows). Squamous metaplasia is often but not always an adaptive change to withstand adverse environmental conditions, such as chronic irritation, and is reversible if the cause is removed. Squamous metaplasia of the glandular stomach most often occurs at the limiting ridge (Figure 1 and Figure 2, arrows). It can be an incidental finding or a treatment-related lesion.
Recommendations:
Whenever present, squamous metaplasia should be diagnosed and graded based on the number and size of metaplastic areas. Associated lesions, such as inflammation, should be diagnosed separately.
References:

Myers RK, McGavin MD. 2007. Cellular and tissue responses to injury. In: Pathologic Basis of Veterinary Disease, 4th ed (McGavin MD, Zachary JF, eds). Mosby, St Louis, MO, 3-62.

National Toxicology Program. 2007. NTP TOX-72. Toxicity Studies of Sodium Dichromate Dihydrate (CAS No. 7789-12-0) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice and Male Balb/c and am3-C57BL/6 Mice. NTP, Research Triangle Park, NC.

Abstract: https://ntp.niehs.nih.gov/go/11170

National Toxicology Program. 2010. NTP TR-558. Toxicology and Carcinogenesis Studies of 3,3’,4,4’-Tetrachloroazobenzene (TCAB) (CAS No. 14047-09-7) in Harlan Sprague Dawley Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.

Abstract: https://ntp.niehs.nih.gov/go/33564
  • Image of metaplasia, squamous in the glandular stomach from a male B6C3F1 mouse in a chronic study

    Stomach, Glandular stomach - Metaplasia, Squamous in a male B6C3F1 mouse from a chronic study. The normal epithelium of the gastric glands is replaced by squamous epithelium (arrow).

Enlarge Image
Enlarge All Images
Stomach, Glandular stomach - Metaplasia, Squamous in a male B6C3F1 mouse from a chronic study. The normal epithelium of the gastric glands is replaced by squamous epithelium (arrow).
Stomach, Glandular stomach - Metaplasia, Squamous in a male B6C3F1 mouse from a chronic study. The normal epithelium of the gastric glands is replaced by squamous epithelium (arrow).
Stomach, Glandular stomach - Metaplasia, Squamous in a male B6C3F1 mouse from a chronic study. The normal epithelium of the gastric glands is replaced by squamous epithelium (arrow).
Stomach, Glandular stomach - Metaplasia, Squamous in a male B6C3F1 mouse from a chronic study. The normal epithelium of the gastric glands is replaced by squamous epithelium (arrow).

Authors:

Linda H. Kooistra, DVM, PhD, DACVP
Pathologist
Charles River Laboratories, Inc.
Research Triangle Park, NC

Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
Expert in Toxicologic Pathology
Visiting Full Professor of Pathology
Sackler School of Medicine, Tel Aviv University Timrat Israel

Reviewers:

Joel R. Leininger, DVM, PhD
Senior Pathologist
MedImmune
Washington, DC

Amy Brix, DVM, PhD, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC