Alimentary System

Tooth, Odontoblast - Necrosis

    Narrative
    Tooth, Odontoblast - Necrosis in a female F344/N rat from a subchronic study. The odontoblasts lining the dorsal tooth pulp are necrotic (arrow).
    Tooth, Odontoblast - Necrosis in a female F344/N rat from a subchronic study. The odontoblasts lining the dorsal tooth pulp are necrotic (arrow).
    Tooth, Odontoblast - Necrosis in a female F344/N rat from a subchronic study (higher magnification of Figure 1). The odontoblasts lining the dorsal tooth pulp have eosinophilic cytoplasm and pyknotic nuclei (arrow) indicative of necrosis.
    Tooth, Odontoblast - Necrosis in a female F344/N rat from a subchronic study (higher magnification of Figure 1). The odontoblasts lining the dorsal tooth pulp have eosinophilic cytoplasm and pyknotic nuclei (arrow) indicative of necrosis.
    Tooth, Odontoblast - Necrosis in a female F344/N rat from a subchronic study. There are 2 regions with necrotic odontoblasts (arrows).
    Tooth, Odontoblast - Necrosis in a female F344/N rat from a subchronic study. There are 2 regions with necrotic odontoblasts (arrows).
    Tooth, Odontoblast - Necrosis in a female F344/N rat from a subchronic study (higher magnification of Figure 3). The odontoblasts have eosinophilic cytoplasm and pyknotic or faded nuclei (arrow) indicative of necrosis.
    Tooth, Odontoblast - Necrosis in a female F344/N rat from a subchronic study (higher magnification of Figure 3). The odontoblasts have eosinophilic cytoplasm and pyknotic or faded nuclei (arrow) indicative of necrosis.

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC