Special Senses System

Eye, Retrobulbar - Hemorrhage

Narrative
Comment:
Hemorrhage of the retrobulbar region (Figure 1 and Figure 2) is characterized by accumulations of extravasated blood. Retrobulbar and/or ocular inflammation may also be present. Such findings are generally the result of trauma from retro-orbital bleeding procedures.
Recommendations:
Retrobulbar hemorrhage should be diagnosed and assigned a severity grade. If it is secondary to another pathologic process (e.g., intraorbital neoplasia), it should not be diagnosed separately, but should be described in the pathology narrative.
References:

National Toxicology Program. 1993. NTP TR-394. Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies). NTP, Research Triangle Park, NC.

Abstract: https://ntp.niehs.nih.gov/go/12239

Van Herck H, Baumans V, Van Der Craats NR, Hesp APM, Meijer GW, Van Tintelen G, Walvoort HC, Beynen AC. 1992. Histological changes in the orbital region of rats after orbital puncture. Lab Anim 6:53-58.

Abstract: http://lan.sagepub.com/content/26/1/53.short
  • Image of retrobulbar hemorrhage in the eye from a male F344/N rat in a chronic study

    Eye, Retrobulbar - Hemorrhage in a male F344/N rat from a chronic study (higher magnification of Figure 1). Hemorrhage (asterisk) of the retrobulbar region with retrobulbar inflammation (R).

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Eye, Retrobulbar - Hemorrhage in a male F344/N rat from a chronic study. There is hemorrhage (arrow) of the retrobulbar region; retrobulbar (R) and ocular (O) inflammation is also present.
Eye, Retrobulbar - Hemorrhage in a male F344/N rat from a chronic study. There is hemorrhage (arrow) of the retrobulbar region; retrobulbar (R) and ocular (O) inflammation is also present.
Eye, Retrobulbar - Hemorrhage in a male F344/N rat from a chronic study (higher magnification of Figure 1). Hemorrhage (asterisk) of the retrobulbar region with retrobulbar inflammation (R).
Eye, Retrobulbar - Hemorrhage in a male F344/N rat from a chronic study (higher magnification of Figure 1). Hemorrhage (asterisk) of the retrobulbar region with retrobulbar inflammation (R).

Author

Margarita M. Gruebbel, DVM, PhD, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Reviewers

Ruth E. Hurley, DVM, PHD, DACVP
Senior Veterinary Pathologist
Huntingdon Life Sciences
North Brunswick, NJ

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC